Innovative drug infusion technology for laboratory animals.

Performance of iPRECIO®      

Method

Pumps, cartridges and infusion protocols

The experiment were carried out using several iPRECIO® Dual pumps and cartridges/cassettes. Where possible/appropriate the total number of points, n is shown with the results.

Continuous infusion, intermittent and bolus accuracies were tested.

Assessment Procedure

The infusion flow-rate was determined by measuring the weight change of a bottle collecting infusate from the outlet of the iPRECIO® Dual pump. An analytical balance was used and the results were automatically recorded on a PC.

Result

Flow Accuracy Test (High & Low Flow)

Flow Accuracy Test(High/2,000)

Flow Accuracy Test(Low/10)


Bolus Infusion Test (High & Low Flow)

Summary of High Flow Bolus Accuracy Data

[10ul/min x 240min (KVO) ⇔ 1000, 1500 or 2000 ul/min × 10min (Bolus)] x 3
KVO  %RSD  1.19  1.6  1.33

Experimental Parameters Data used for Quality Check (Data for graph)
Bolus Flow Rate Each Bolus Duration KVO Flow rate Each KVO Duration Total Test Duration Number of Measurement Points %RSD Bolus Data:Number of Points KVO Data:Number of Points Number of Cartridges Tested Accuracy Tolerance
*(min) for 3 KVO and 3 Bolus *30 second durations *1 minute duration measurement points *30 minutes duration measurement points
1,000µL/min 10min 10µL/min 240min 750min 1,500 0.63 27 63 5 +/-5%
1,500µL/min 10min 10µL/min 240min 750min 1,500 0.67 27 63 5 +/-5%
2,000µL/min 10min 10µL/min 240min 750min 1,500 0.74 27 63 5 +/-5%




Summary of Low Flow Bolus Accuracy Data

[10ul/min x 240min (KVO) ⇔ 20, or 50 ul/min × 60min (Bolus) ] x 3
KVO  %RSD  1.03%  0.81%

Experimental Parameters Data used for Quality Check (Data for graph)
Bolus Flow Rate Each Bolus Duration KVO Flow rate Each KVO Duration Total Test Duration Number of Measurement Points %RSD Bolus Data:Number of Points KVO Data:Number of Points Number of Cartridges Tested Accuracy Tolerance
*(min) for 3 KVO and 3 Bolus *30 second durations *5 minutes duration measurement points *30 minutes duration measurement points
20µL/min 60min 10µL/min 240min 900min 1,800 0.92 30 21 2 +/-5%
50µL/min 60min 10µL/min 240min 900min 1,800 1.79 30 21 2 +/-5%



Trumpet Curve

Trumpet Curve Graph 10micro

Trumpet Curve Graph 50micro

Trumpet Curve Graph 100micro

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