The table below summarizes selected example use of iPRECIO® in Japan. These pumps have mainly been used in rats but have also been used in goat, non human primates, rabbits and guinea pigs. Due to iPRECIO® pumps small size, good accuracy and functionality, they have also been used with mice with a tether system where they replaced the syringe pump. With such a compact system; animal, cage and pump may be isolated very easily, for example isolated and metabolic cages.

The technology report summarizes additional application details from various publications and includes 5 examples from United States and Europe:-

1. Dependence and withdrawal in the same cohort
2. Rapid and long term delivery of drug with radiotelemetry (blood pressure endpoint)
3. Dose response curve within an individual animal with radiotelemetry (blood pressure endpoint)
4. Dose response of multiple drugs, within a single animal with radiotelemetry (systemic and ventricular pressure endpoints)
5. Drug exposure levels in blood for 3 dose profiles (PK)

Customer	Animal	Drug	Administration Route	Mode	Flow-rate
Pharmaceutical Company	Rat	The toxicity test of a circulation related medicine	External jugular vein	Confidential	Confidential
Pharmaceutical Company	Rat	Reproductive hormone	External jugular vein	RCV/Constant	5-10
Pharmaceutical Company	Rat	Diabetes related medicine	External jugular vein	RCV/Variable	3-15
Pharmaceutical Company	Rat	Epilepsy related medicine	Injection in the skull	RCV/Constant	1-10
Pharmaceutical Company	Rat	Antiphlogistic-sedative-drug relation	Subcutaneous	RCV/Constant	1-20
Pharmaceutical Company	Rat	Ophthalmology region medicine	Fundus oculi	RCV/Constant	3-15
Pharmaceutical Company	Rat	Metabolism related	External jugular vein	RCV/Constant	5-10
Pharmaceutical Company	Rat	pH5 strong acidity solution	Subcutaneous	Confidential	Confidential
Fukuyama University	Rat	Pain	Subcutaneous	Confidential	Confidential
Gifu university	Rat	Angiotensin 2	External jugular vein	Instant/Variable	3-30
		Losartan
Hoshi University	Hamster	Confidential	External jugular vein and Subcutaneous	RCV/Constant	1-15
Hoshi University	Rat	Confidential	External jugular vein	RCV/Constant	5-30
Hoshi University	Rat	pain clinic related	Hypodermoclysis	RCV/Constant	1-30
Jichi Medical University	Mouse	Confidential	Subcutaneous	Confidential	Confidential
Nagoya City University	Rat	Angiotensin 2	External jugular vein	Confidential	Confidential
National Institute of Agrobiological Sciences	Goat	Confidential	Vein	RCV/Constant	5-30
National Center of Neurology and Psychiatry (NCNP)	Mouse	Confidential	Subcutaneous	RCV/Constant	1-15
Nihon University	Rat	Confidential	External jugular vein	RCV/Constant	3-10
Osaka City University	Rat	Neurotransmitter	Injection in the skull	RCV/Constant	1-15
Osaka University of Pharmaceutical Sciences	Rat	VitamineB12	External jugular vein	Confidential	Confidential
Shiga University of Medical Science	Confidential	Reproduction related	Subcutaneous	Instant/Variable	1-7
Shiga University of Medical Science	Rat	Reproductive hormone	External jugular vein	RCV/Constant	5-10
Tokyo Women's Medical University (TWMU)	Hamster	Confidential	External jugular vein and Subcutaneous	RCV/Constant	1-15
The University of Tokyo	Rat	Nicotine	External jugular vein	Confidential	Confidential
The University of Tokyo	Rat	Confidential	External jugular vein	RCV/Constant	5-15

 

For more details on applications, see bibliography section (here) and iPRECIO® Application and Technology Report (here)