Innovative drug infusion technology for laboratory animals.
7 new publications including Circadian and Pulsatile delivery. See https://www.iprecio.com/support/tabid/196/Default.aspx and https://www.iprecio.com/support/tabid/161/Default.aspx for full details. Here are 3:-
Tochinai, Ryota, et al. Ivabradine ameliorates cardiomyopathy progression in a Duchenne muscular dystrophy model rat. [Open Access] Experimental Animals (2023): 23-0087. https://www.jstage.jst.go.jp/article/expanim/advpub/0/advpub_23-0087/_article/-char/ja/ Key words: dystrophin deficiency, echocardiography, HCN channel, heart, tachycardia
Joshi, Pooja, et al. Ryanodine receptor 2 inhibition reduces dispersion of cardiac repolarization, improves contractile function and prevents sudden arrhythmic death in failing hearts. [Open Access] eLife 12 (2023) https://elifesciences.org/reviewed-preprints/88638v2 Keywords: Sudden cardiac death (SCD), heart failure (HF), ventricular tachycardia/fibrillation (VT/VF)
Bering, Tenna, et al., Circadian Clock Genes Are Regulated by Rhythmic Corticosterone at Physiological Levels in the Rat Hippocampus. Neuroendocrinology 113.10 (2023): 1076-1090. https://karger.com/nen/article/113/10/1076/860659 Keywords: Clock gene, Corticosterone, Hippocampus, Programmable pumps, Suprachiasmatic nucleus
[Webinar] DATE: Wednesday, September 20, 2023 iPRECIO Micro Infusion Pump by Primetech Corporation sponsors Test Method Webinar. Learn about the webinar New Horizons: Gonadotropin-Releasing Hormone and Cognition by the joining Vincent Prevot, PhD as he dives into the development and establishment of the gonadotropin-releasing hormone (GnRH) system and the importance of its first postnatal activation. The webinar series Neurophysiology: Exploring Basic Research & Clinical Consequences is with the American Physiological Society, Society for Neuroscience, Federation of European Neuroscience Societies - FENS, and the American Autonomic Society! Webinar and related Scientific Publications details have been updated in our iPRECIO Application Booklet on page 23. Contact iPRECIO Micro Infusion Pumps by Primetech Corporation.
7 new publications: Four in Nature Aging (2023), Laboratory Investigation 103.1 (2023), Endocrinology 164.4 (2023) and Epilepsy Research (2023) respectively. 4 at preprint stage in bioRxiv (2023). See https://www.iprecio.com/support/tabid/196/Default.aspx and https://www.iprecio.com/support/tabid/161/Default.aspx for full details. Here are 2:- Moigneu, Carine, et al. "Systemic GDF11 attenuates depression-like phenotype in aged mice via stimulation of neuronal autophagy." Nature Aging (2023): 1-16. https://www.nature.com/articles/s43587-022-00352-3 [Open Access] Hasegawa, Tomoka, et al. "Evocalcet Rescues Secondary Hyperparathyroidism-driven Cortical Porosity in CKD Male Rats." Endocrinology 164.4 (2023): bqad022. https://academic.oup.com/endo/article/164/4/bqad022/7013989[Open Access]
Recent user/customer feedback; " Thank your company for developing this miniaturized programmable pump that has really been a game changer in this work (and promise to be of tremendous help in the field of Neuroendocrinology, Endocrinology and Metabolism in the future) and enabled the completion of preclinical studies in mice that paved the way to human clinical trials. "
Discovery and Characterization of JDQ443: a Structurally Novel Covalent Inhibitor of KRASG12C Elizabeth McKenna, PhD, interviews Saskia Brachmann, PhD, Anna Farago, MD, PhD, and Andreas Weiss, PhD, about their paper describing a novel KRAS G12C inhibitor that was published concurrently with a Clinical Trials Minisymposium presentation at the 2022 AACR Annual Meeting. aacrjournals.org/cancerdiscovery/article/12/6/1500/699171 https://vimeo.com/720726054 iPRECIO SMP-310R Programmable pumps were used to better understand the relationship between PK, target occupancy, and efficacy.
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