Christian Schnell's (Novartis Oncology) talk on "Challenges in enabling translation of tumor models in cancer therapy: Exploiting secreted luciferases to monitor tumor metastasis as a promising approach" at the Swiss 3Rs Day 2024 in the AGORA Cancer Research Centre in Lausanne. Recording sponsored by Primetech Corporation – makers of iPRECIO^® Programmable Pumps.

https://www.youtube.com/watch?v=7Tcdb4L3gCY

Sponsored 2024 3Rs Sharing Conference April 17, 2024
Genentech Campus, San Francisco, California
An in-person discussion-focused 3Rs conference hosted by the 3Rs Collaborative and the New Jersey Association for Biomedical Research.

Check out agenda https://3rc.org/3rs-sharing-conference/

Published: 30 January 2024 from Genentech, 1 DNA Way, South San Francisco,
An, Le, Tom De Bruyn, Jodie Pang, Savita Ubhayakar, Laurent Salphati, Xing Zhang, Liling Liu et al. "Early Stage Preclinical Formulation Strategies to Alter the Pharmacokinetic Profile of Two Small Molecule Therapeutics." Pharmaceuticals 17, no. 2 (2024): 179.
https://www.mdpi.com/1424-8247/17/2/179

Keywords: drug delivery; PO; IV infusion; IP; SC; small molecule; PK profile; exposure

Download and install our Latest Application Software for IMS/SMP-310R which was released in January 2024. Includes Release Notes. Go to our support page
https://www.iprecio.com/support/tabid/262/Default.aspx

6 new publications including 2 with STAR*METHODS (https://www.cell.com/cell/fulltext/S0092-8674(16)31072-8).
These two publications mention administrating clinically relevant doses.

Rodrigues, Marinelle, et al. "Susceptible bacteria “can” survive antibiotic treatment in the mammalian gastrointestinal tract without evolving resistance." Cell Host & Microbe (2024).
https://www.sciencedirect.com/science/article/abs/pii/S1931312824000167
Keywords: antibiotic resistance; antibiotic persistence; antibiotic tolerance; mammalian GI tract; bacterial survival; Escherichia coli; bacterial virulance

Giri, Tusar, et al. "Oxytocin Induced Birth Causes Sex Specific Behavioral and Brain Connectivity Changes in Developing Rat Offspring." Iscience (2024). https://www.sciencedirect.com/science/article/pii/S2589004224001810 [Open Access]
Subject areas: Endocrinology; Neuroscience; Behavioral neuroscience

7 new publications including Circadian and Pulsatile delivery.
See https://www.iprecio.com/support/tabid/196/Default.aspx and https://www.iprecio.com/support/tabid/161/Default.aspx for full details. Here are 3:-

Tochinai, Ryota, et al.
Ivabradine ameliorates cardiomyopathy progression in a Duchenne muscular dystrophy model rat. [Open Access]
Experimental Animals (2023): 23-0087.
https://www.jstage.jst.go.jp/article/expanim/advpub/0/advpub_23-0087/_article/-char/ja/
Key words: dystrophin deficiency, echocardiography, HCN channel, heart, tachycardia

Joshi, Pooja, et al.
Ryanodine receptor 2 inhibition reduces dispersion of cardiac repolarization, improves contractile function and prevents sudden arrhythmic death in failing hearts. [Open Access]
eLife 12 (2023)
https://elifesciences.org/reviewed-preprints/88638v2
Keywords: Sudden cardiac death (SCD), heart failure (HF), ventricular tachycardia/fibrillation (VT/VF)

Bering, Tenna, et al.,
Circadian Clock Genes Are Regulated by Rhythmic Corticosterone at Physiological Levels in the Rat Hippocampus.
Neuroendocrinology 113.10 (2023): 1076-1090.
https://karger.com/nen/article/113/10/1076/860659
Keywords: Clock gene, Corticosterone, Hippocampus, Programmable pumps, Suprachiasmatic nucleus