Innovative drug infusion technology for laboratory animals.

Support Materials of iPRECIO®       

You can request for our support materials of your interest from our contact us page from this website.

Support Documents and Technical Notes   Bibliography

Support Documents and Technical Notes

Compatibility test <Compatible solvents/vehicles for iPRECIO>

You can request for our support materials of your interest from our contact us page from this website.

Frequently Asked Questions <FAQ>

This FAQ incorporates the most frequent question and answers for iPRECIO pumps.

Technical Note : Performance of the iPRECIO® Pumps.

Flow infusion accuracy of iPRECIO pumps (in-vitro testing). Contents of this technical note is included in the technology page. See Performance of iPRECIO pumps (in-vitro testing) page.

Technical Note : Recommendation for Intravenous Administration.

This technical note outlines best practice implantation for iPRECIO pumps for long term continuous administration.

*Includes recommendation of catheters and couplers.

Technical Note : Recommendations for Subcutaneous Administration.

This technical note defines best practice subcutaneous infusion administration site and iPRECIO pump placement and implantation.

Technical Note : Recommendations for Intraperitoneal Administration.

This technical note defines best practice intraperitoneal infusion administration site and iPRECIO pump placement and implantation.

Technical Note : Recommendations for Intracerebral Administration.

This technical note defines best practice intracerebral infusion administration site and iPRECIO pump placement and implantation. 322OP: Starter Kit Cranial Infusion Kit for iPRECIO® Pump and 322OP/Kit: Cranial Infusion Kit for iPRECIO® pump are supplied by Plastics One ® (

Technical Note : Recommendations for Intrathecal Administration

This technical note defines the best practice intrathecal infusion administration using iPRECIO® pumps with customized intrathecal catheter part number 0220 from Recathco(

Technical Note : Materials Compatibility Kit for iPRECIO® Pump

This technical note defines the Standard Operating Procedure (SOP) for evaluating the compatibility of vehicle/solvents and agents to iPRECIO®.

Technical Note : SOPsfor fow validation of iPRECIO® pumps.

This technical note defines the Standard Operating Procedure (SOP) for flow accuracy validation based on residual/remaining solution in iPRECIO pumps.

Back to top


Withey, Sarah L., Jack Bergman, and Carol A. Paronis.
The effects of chronic naltrexone on reinstatement of opioid-induced drug-seeking behavior and antinociception.
Journal of Pharmacology and Experimental Therapeutics 389.1 (2024): 5-14.

Subject: Opioid Addiction, Naltrexone, Drug-seeking behavior

Withey, Sarah L., Diego A. Pizzagalli, and Jack Bergman.
Translational In Vivo Assays in Behavioral Biology. [Open Access]
Annual Review of Pharmacology and Toxicology 64 (2024): 435-453.
(Related Withey, Sarah L., Jack Bergman, and Carol A. Paronis. (2024) )

Keywords: Research Domain Criteria, RDoC, behavioral pharmacology, translational research, behavioral neuroimaging, behavioral electrophysiology, drug discovery

Barrett, James E.
A Statement on the Pharmacology of Reinstatement: Naltrexone and Relapse to Opioid Seeking. [Open Access]
Journal of Pharmacology and Experimental Therapeutics 389.1 (2024): 1-4.
(Related Withey, Sarah L., Jack Bergman, and Carol A. Paronis. (2024))

Subject: Opioid Addiction, Naltrexone, Drug-seeking behavior

Ribot, Bastien, et al.
Striatal Cholinergic Agonist Infusion Induces a Dystonic Phenotype in Non-human Primate (S26. 010).

Neurology. Vol. 102. No. 17_supplement_1. Hagerstown, MD: Lippincott Williams & Wilkins, 2024.

Keywords: cholinergic system dysregulation, pathophysiology of dystonia.

Manrique-Huarte, Raquel, et al.
Acute histological reactions in the otolith organs to inner ear drug delivery through a cochlear implant.

Frontiers in Neurology 15 (2024): 1363481.

Keywords: cochlear implant, vestibular dysfunction, histological vestibular reaction, hydrops, inner ear delivery

Mottolese, Nicola.
Role of neuroinflammation in the pathophysiology of CDKL5 deficiency disorder.

Keywords: CDKL5, Neuroinflammation, Neuronal survival, Luteolin

Giri, Tusar, et al.
Oxytocin Induced Birth Causes Sex Specific Behavioral and Brain Connectivity Changes in Developing Rat Offspring. [Open Access]
iScience (2024): 108960

Subject areas: Endocrinology; Neuroscience; Behavioral neuroscience

Devlin MacKeigan et al.
Chronic intermittent convection-enhanced delivery of vigabatrin to the bilateral subthalamic nucleus in an acute rat seizure model. [Open Access]
Epilepsy Research 199 (2024): 107276.

Keywords: Basal ganglia; Epilepsy; GABA transaminase Intracerebral pharmacotherapy; Pentylenetetrazole Tolerance

Gulledge, Michael, et al.
Spontaneous oxycodone withdrawal disrupts sleep, circadian, and electrophysiological dynamics in rats. [Open Access]
bioRxiv (2024): 2024-01

Keywords: Basal ganglia, Epilepsy, GABA transaminase, Intracerebral pharmacotherapy, Pentylenetetrazole Tolerance

De Bie, Felix R., et al.
Prenatal treprostinil improves pulmonary arteriolar hypermuscularization in the rabbit model of congenital diaphragmatic hernia. [Open Access]
Biomedicine & Pharmacotherapy 170 (2024): 115996.

Keywords: Foetal therapy; pulmonary hypertension; congenital diaphragmatic hernia; treprostinil

Harder, Hannah.
Long-Term Immune Consequences of Perinatal Opioid Exposure. [Open Access]
Dissertation, Georgia State University, 2023.

INDEX WORDS: Morphine, Perinatal, Lipopolysaccharide, Immunity, Microglia, Microbiota

Joshi, Pooja, et al.
Ryanodine receptor 2 inhibition reduces dispersion of cardiac repolarization, improves contractile function and prevents sudden arrhythmic death in failing hearts. [Open Access]
eLife 12 (2023)

Keywords: Sudden cardiac death (SCD), heart failure (HF), ventricular tachycardia/fibrillation (VT/VF)

Bering, Tenna, et al.,
Circadian Clock Genes Are Regulated by Rhythmic Corticosterone at Physiological Levels in the Rat Hippocampus.
Neuroendocrinology 113.10 (2023): 1076-1090.

Keywords: Clock gene, Corticosterone, Hippocampus, Programmable pumps, Suprachiasmatic nucleus

MacKeigan, Devlin, et al.
Long-lasting antiseizure effects of chronic intrasubthalamic convection-enhanced delivery of valproate. [Open Access]
Neurobiology of Disease 187 (2023): 106321.

Keywords: Basal ganglia, Intracerebral drug delivery, Epilepsy, Subthalamic nucleus

Sato, Akira, et al.
Generation of a familial hypercholesterolemia model in non-human primate. [Open Access]
Scientific Reports 13.1 (2023): 15649.

Subjects: Biochemistry, Endocrinology

Harder, Hannah J., et al.
Perinatal opioid exposure leads to decreased social play in adolescent male and female rats: Potential role of oxytocin signaling in brain regions associated with social reward.
Hormones and Behavior 153 (2023): 105384.

Keywords: Neonatal opioid withdrawal syndrome, Juvenile play, Social play, Morphine

Rotolo, Renee A., et al.
Effort-related effects of chronic administration of the DA D2 receptor antagonist haloperidol via subcutaneous programmable minipumps: Reversal by co-administration of the adenosine A2A antagonist istradefylline.
Psychopharmacology (2023): 1-13.

Keywords Dopamine · Motivation · Avolition · Negative · Symptoms · Schizophrenia

Martinez–Arguelles, Daniel B., et al.
Oral administration of VDAC1-derived small molecule peptides increases circulating testosterone levels in male rats. [Open Access]
Frontiers in Endocrinology 13 (2023): 1003017.

Keywords: testosterone, Leydig cell, hypogonadism, aging, small molecule, therapeutics

Baggett, Brett C., et al.
Myofibroblast senescence promotes arrhythmogenic remodeling in the aged infarcted rabbit heart. [Open Access]
Elife 12 (2023): e84088.

Hasegawa, Tomoka, et al.
Evocalcet Rescues Secondary Hyperparathyroidism-driven Cortical Porosity in CKD Male Rats. [Open Access]
Endocrinology 164.4 (2023): bqad022.

Key Words: secondary hyperparathyroidism, evocalcet, cortical porosity, osteocyte, Phex/SIBLING

Gernert, Manuela, et al.
Acute and chronic convection-enhanced muscimol delivery into the rat subthalamic nucleus induces antiseizure effects associated with high responder rates. [Open Access]
Epilepsy Research (2023): 107097.

Key Words: Basal ganglia, Epilepsy, Intracerebral drug delivery, Microinjection, Pentylenetetrazole, Pharmacoresistance

DeMazumder, Deeptankar, et al.
Molecular and cellular mechanisms by which cardiac sympathetic denervation prevents heart failure and sudden cardiac arrest. [Open Access]Preprint
bioRxiv (2023): 2023-01

Fabrèges, Dimitri, et al.
Temporal variability and cell mechanics control robustness in mammalian embryogenesis. [Open Access]Preprint
bioRxiv (2023): 2023-01

Joshi, Pooja, et al.
Ryanodine receptor inhibition improves cardiac repolarization reserve and contractile function and prevents sudden arrhythmic death in failing hearts. [Open Access]Preprint
bioRxiv (2023): 2023-01

Turner, Mandy E., et al.
The 1, 24, 25 (OH) 3D3 metabolite in clinical and experimental CKD: Impact of calcitriol treatment.
The Journal of Steroid Biochemistry and Molecular Biology (2022): 106207

Key Words: Calcitriol, CYP24A1, chronic kidney disease, vitamin D, experimental

Fukushi, Yasuko, et al.
The Cholinergic Pathway and MitoKATP Induce UCP4 Expression Involved in Neuroprotection of FN Stimulation in Rats. [Open Access]
Stroke: Vascular and Interventional Neurology (2022): e000362.

Key Words: brain injury, ischemic tolerance, middle cerebral artery occlusion, reactive oxygen species, uncoupling protein

Giri, Tusar, et al.
Labor induction with oxytocin in pregnant rats is not associated with oxidative stress in the fetal brain.
Scientific reports 12.1 (2022): 1-12.

Bering Tenna, Hertz Henrik, Rath Martin Fredensborg
The Circadian Oscillator of the Cerebellum: Triiodothyronine Regulates Clock Gene Expression in Granule Cells in vitro and in the Cerebellum of Neonatal Rats in vivo
Frontiers in Physiology Vol. 12 (2021) 1901, doi. :10.3389/fphys.2021.706433

Key words: thyroid hormone, T3, cerebellum, clock gene, circadian, suprachiasmatic nucleus, iPRECIO programmable micropump

Karoor, Vijaya, Delaney Swindle, David Pak, Derek Strassheim, Mehdi A Fini, Edward Dempsey, Kurt R Stenmark, et al.
EXPRESS: Evidence Supporting a Role for Circulating Macrophages in the Regression of Vascular Remodeling Following Sub-Chronic Exposure to Hemoglobin plus Hypoxia
Pulmonary Circulation, (November 2021), doi.:10.1177/20458940211056806

Key words: Hemoglobin, Macrophages, Pulmonary Hypertension, heme

Tusar Giri, Jia Jiang, Zhiqiang Xu, Ronald Mccarthy, Carmen M. Halabi, Eric Tycksen, Alison G. Cahill, Sarah K. England, Arvind Palanisamy
doi. : (preprint)

Key words : pregnant rat; animal model; oxytocin; labor induction; uterine myometrium; fetal brain; oxidative stress; intrauterine telemetry; oxytocin receptor; RNA-sequencing

Steplewski A, Fertala J, Tomlinson RE, Wang ML, Donahue A, Arnold WV, et al.
Mechanisms of reducing joint stiffness by blocking collagen fibrillogenesis in a rabbit model of posttraumatic arthrofibrosis.
PLoS ONE 16(9): e0257147 doi. :

Subject Areas : Collagens, Rabbits, Scars, Knees, Wound healing, Skeletal joints, Histology, Tendons

R Manrique-Huarte, Marta Alvarez de Linera-Alperi, D Parilli, JA Rodriguez, D Borro, WF Dueck, D Smyth, A Salt, M Manrique
Inner ear drug delivery through a cochlear implant: Pharmacokinetics in a Macaque experimental model [Open Access]
Hearing Research, Volume 404, 2021
108228, ISSN 0378-5955, doi.:10.1016/j.heares.2021.108228

Peer B. Jacobson, Robin Goody, Matthew Lawrence, Xiaomeng Zhang, Bradley A. Hooker, Kimberly Pfleeger, Adam Ziemann, Charles Locke, Quentin Barraud, Mathias Droescher, Joerg Bernhard, Andreas Popp, Preethne Boeser, Lili Huang, Jennifer Mollon, Yulia Mordashova, Yi-Fang Cui, John P. Savaryn, Christine Grinnell, Ingeborg Dreher, Michael Gold, Grégoire Courtine, Andrea Mothe, Charles H. Tator, James D. Guest
Elezanumab, a human anti-RGMa monoclonal antibody, promotes neuroprotection, neuroplasticity, and neurorecovery following a thoracic hemi-compression spinal cord injury in non-human primates [Open Access]
Neurobiology of Disease, Available online 12 May 2021, 105385
DOI: 10.1016/j.nbd.2021.105385

Francesca Marchionne, Alexander J. Krupka, George M. Smith, Michel A. Lemay
Intrathecal Delivery of BDNF into the Lumbar Cistern Re-Engages Locomotor Stepping after Spinal Cord Injury
IEEE Transactions on Neural Systems and Rehabilitation Engineering
DOI: 10.1109/TNSRE.2020.3027393

Index Terms: animal model, intrathecal, locomotion, neurotrophin, spinal cord injury

Peter Warn, Pia Thommes, Andrew Sharp, Abdul Sattar, Nasrullah Undre, Jose Alejandro Palacios-Fabrega, Andreas Karas
Intermittent micafungin for prophylaxis in a rat model of chronic Candida albicans gut colonization
Journal of Antimicrobial Chemotherapy, dkaa243, Published: 28 July 2020

Topic: candida albicans, feces, rats, mica fungin, microbial colonization prevention

Kelly Hyndman, Joshua S. Speed, Luciano D. Mendoza, John Allan, Jackson Colson, Randee Sedaka, Chunhua Jin, Hyun Jun Jung, Samir El-Dahr, David Pollock, and Jennifer Pollock.
Fluid-electrolyte homeostasis requires histone deacetylase function [Open Access]
First published July 16, 2020 , In Press Preview 10.1172/jci.insight.137792

Subjects: Cell Biology, Nephrology
Keywords: Histone deacetylase, high salt, kidney, blood pressure, natriuresis, diuresis, nitric oxide

Nikki Luis Bennett, Christopher L. Zambataro, Troy Velie, Heather Bogie, Sheerin Luis Shahidi-Latham, Brian Ferguson, Carlos Luis del Rio
Pilot Evaluation of Telemetered Cardiac Hemodynamics in the Setting of Fully‐Implanted Programmable Drug Delivery in Rats: A New Tool for Cardiovascular Drug Discovery?
Volume34, IssueS1, Supplement: Experimental Biology 2020 Meeting Abstracts April 2020

Tomomi Yamamoto-Fukuda MD, PhD Naotaro Akiyama MD, PhD Hiromi Kojima MD, PhD
L1CAM–ILK–YAP mechanotransduction drives proliferative activity of epithelial cells in middle ear cholesteatoma.
The American Journal of Pathology, Available online 29 April 2020

Mykel A Robble, Ph.D, Isaiah L Holloway, Jr, B.S, Elysia Ridener, M.S, Chelsea J Webber, M.S, S Barak Caine, Ph.D, Edward Meloni, Ph.D, Rajeev I Desai, Ph.D, William A Carlezon, Jr, Ph.D
Differential effects of nicotine and nicotine withdrawal on fear conditioning in male rats
[Open Access]
International Journal of Neuropsychopharmacology, pyaa024,

Key words: Nicotine, PTSD, Fear Conditioning, Withdrawal
Topic: nicotine, nicotine withdrawal, conditioning (psychology), fear, self-administration, rats

Seita, Yasunari; Morimura, Toshifumi; Watanabe, Naoki; Watani, Chizuru; Tsuchiya, Hideaki; Nakamura, Shinichiro; Suzuki, Toshiharu; Yanagisawa, Daijiro; Tsukiyama, Tomoyuki; Nakaya, Masataka; Okamura, Eiichi; Muto, Masanaga; Ema, Masatsugu; Nishimura, Masaki; Tooyama, Ikuo
Generation of Transgenic Cynomolgus Monkeys Overexpressing the Gene for Amyloid-β Precursor Protein
[Open Access]
Journal of Alzheimer's Disease, vol. Pre-press, no. Pre-press, pp. 1-16, 2020

Key words: Amyloid-beta protein precursor, animal, cryopreservation, intracytoplasmic sperm injection (ICSI), primates, transgenic, vitrification, zygote

Miss Amanda Cheung, Dr. Femke Streijger, Miss Kitty So, Dr. Elena B Okon, Ms. Neda Manouchehri, Ms. Katelyn Shortt, Prof. Kyoung-Tae Kim, Mr. Martin Keung, Mr. Ryan M Chan, Mr. Allan Fong, Miss Jenny Sun, Dr. Donald E Griesdale, Dr. Mypinder Singh Sekhon, and Dr. Brian K Kwon
The Relationship Between Early Vasopressor Administration and Spinal Cord Hemorrhage in a Porcine Model of Acute Traumatic Spinal Cord Injury
Journal of Neurotrauma, Just Accepted, Published Online:1 Apr 2020

Key words: animal studies, clinical management of CNS injury, Models of Injury, Traumatic Spinal Cord Injury

Meihua Li, Can Zheng, Toru Kawada, Masashi Inagaki, Kazunori Uemura & Masaru Sugimachi
Intracerebroventricular infusion of donepezil prevents cardiac remodeling and improves the prognosis of chronic heart failure rats
[Open Access]
The Journal of Physiological Sciences volume 70, Article number: 11 (2020)

Tomoyuki Tsukiyama, Kenichi Kobayashi, Masataka Nakaya, Chizuru Iwatani, Yasunari Seita, Hideaki Tsuchiya, Jun Matsushita, Kahoru Kitajima, Ikuo Kawamoto, Takahiro Nakagawa, Koji Fukuda, Teppei Iwakiri, Hiroyuki Izumi, Iori Itagaki, Shinji Kume, Hiroshi Maegawa, Ryuichi Nishinakamura, Saori Nishio, Shinichiro Nakamura, Akihiro Kawauchi & Masatsugu Ema
Monkeys mutant for PKD1 recapitulate human autosomal dominant polycystic kidney disease
[Open Access]
Nature Communications volume 10, Article number: 5517 (2019)

Subjects: Disease Model, Genetic Engineering, Mechanism of Disease

Sarah L.Withey Rachel J.Doyle Erica N.Portera JackBergman Brian D.Kangas
Discrimination Learning in Oxycodone-Treated Nonhuman Primates
Drug and Alcohol Dependence, Available online 27 November 2019, 107778

Henrike Beverungen, Samantha Choyke Klaszky, Michael Klaszky, and Marie-Pascale Côté
Rehabilitation Decreases Spasticity by Restoring Chloride Homeostasis through the Brain-Derived Neurotrophic Factor–KCC2 Pathway after Spinal Cord Injury
Journal of Neurotrauma 2019 doi: 10.1089/neu.2019.6526

Key words: spinal cord injury, rehabilitation, chloride homeostasis, neuroplasticity, KCC2

K. Redinus et al.
An Hb-mediated circulating macrophage contributing to pulmonary vascular remodeling in sickle cell disease
JCI Insight. 2019 Aug 8; 4(15): e127860.
Published online 2019 Aug 8. doi:

Bering T, Hertz H, Rath M.
Rhythmic release of corticosterone induces circadian clock gene expression in the cerebellum.
Neuroendocrinology. 2019 Sep 27. doi: 10.1159/000503720. [Epub ahead of print]

Yi Gong, Ming-yue Du, Hua-lin Yu, Zhi-yong Yang, Yu-jin Li, Lei Zhou, Rong Mei, Li Yang, Fei Wang
Increased TRPM4 Activity in Cerebral Artery Myocytes Contributes to Cerebral Blood Flow Reduction After Subarachnoid Hemorrhage in Rats
Neurotherapeutics pp1-11, 09 May 2019,

Yasunari Seita,  Tomoyuki Tsukiyama,  Takuya Azami,  Kenichi Kobayashi,  Chizuru Iwatani,  Hideaki Tsuchiya, Masataka Nakaya,  Hideyuki Tanabe,  Seiji Hitoshi,  Hiroyuki Miyoshi,  Shinichiro Nakamura, Akihiro Kawauchi,  Masatsugu Ema
Comprehensive evaluation of ubiquitous promoters suitable for the generation of transgenic cynomolgus monkeys
Biology of Reproduction, ioz040,

Bo Halle, Kristian Mongelard, Frantz Rom Poulsen
Convection‑enhanced Drug Delivery for Glioblastoma: A Systematic Review Focused on Methodological Differences in the Use of the Convection‑enhanced Delivery Method
Asian Journal of Neurosurgery, Review Article, Year:2019, Volume:14, Issue:1, Page:5-14, DOI:10.4103/ajns.AJNS_302_17;year=2019;volume=14;issue=1;spage=5;epage=14;aulast=Halle

Yasunari SEITA, Chizuru IWATANI, Hideaki TSUCHIYA, Shinichiro NAKAMURA, Fuminori KIMURA, Takashi MURAKAMI, Masatsugu EMA
Poor second ovarian stimulation in cynomolgus monkeys (Macaca fascicularis) is associated with the production of antibodies against human follicle-stimulating hormone
Journal of Reproduction and Development, March 07, 2019, doi:10.1262/jrd.2018-156

W. A. Carlezon, Jr, I. Holloway, M. A. Robble, E. Meloni, R. Desai
Chronic intermittent nicotine exposure attenuates conditioned fear: A therapeutic model of the nicotine patch (P414.13)
Neuroscience 2018, Nov 3rd to 7th. San Diego CA.

Marty Cauley, Brandon J. Hall, Yael Abreu-Villaça, Shaqif Junaid, Hannah White, Abtin Kiany, Theodore A. Slotkin, Edward D. Levin
Critical developmental periods for effects of low-level tobacco smoke exposure on behavioral performance
NeuroToxicology, Volume 68, September 2018, Pages 81-87

Swati Dey, Deeptankar DeMazumder, Agnieszka Sidor, D B Foster, Brian O'Rourke
Mitochondrial ROS Drive Sudden Cardiac Death and Chronic Proteome Remodeling in Heart Failure
Circulation Research. 2018;CIRCRESAHA.118.312708

Yasuto Shikida, Masahide Mizobuchi,Takashi Inoue, Toma Hamada, Hiroaki Ogata, Fumihiko Koiwa, Takanori Shibata
Effect of Continuous Intravenous Calcium Loading on Fibroblast Growth Factor 23 in Normal and Uremic Rats
Calcified Tissue International(2018) pp1-10

Dmitry V.Zaretsky, Hannah Kline, Maria V.Zaretskaia, Mary Beth Brown, Pamela J.Durant, Nathan J.Alves, Daniel E.Rusyniak
Disinhibiting neurons in the dorsomedial hypothalamus delays the onset of exertional fatigue and exhaustion in rats exercising in a warm environment
Brain Research Available online 22 March 2018

David Romeo-Guitart, Joaquim Forés, Mireia Herrando-Grabulosa, Raquel Valls, Tatiana Leiva-Rodríguez, Elena Galea, Francisco González-Pérez, Xavier Navarro, Valerie Petegnief, Assumpció Bosch, Mireia Coma, José Manuel Mas & Caty Casas
Neuroprotective Drug for Nerve Trauma Revealed Using Artificial Intelligence
SCIENTIFIC REPORTS (2018) 8:1879 DOI:10.1038/s41598-018-19767-3, January 2018

Dr. Femke Streijger, Miss Kitty So, Ms. Neda Manouchehri, Ms. Ana Gheorghe, Dr. Elena B Okon, Mr. Ryan M Chan, Mr. Benjamin Ng, Ms. Katelyn Shortt, Dr. Mypinder Singh Sekhon, Dr. Donald E Griesdale, and Dr. Brian K Kwon.
A Direct Comparison Between Norepinephrine and Phenylephrine for Augmenting Spinal Cord Perfusion in a Porcine Model of Spinal Cord Injury
Journal of Neurotrauma. January 2018

Zengbing Lu, Man P. Ngan, Ge Lin, David T.W. Yew, Xiaodan Fan, Paul L.R. Andrews and John A. Rudd
Gastric myoelectric activity during cisplatin-induced acute and delayed emesis reveals a temporal impairment of slow waves in ferrets: effects not reversed by the GLP-1 receptor antagonist, exendin (9-39)
Oncotarget. 2017 Nov 17; 8(58): 98691–98707. doi: 10.18632/oncotarget.21859

Dr. Femke Streijger, Miss Kitty So, Ms. Neda Manouchehri, Mr. Jae H.T. Lee, Dr. Elena B Okon, Ms. Katelyn Shortt, Ms. So-Eun Kim, Mr. Kurt Anthony McInnes, Dr. Peter Alec Cripton, and Dr. Brian K Kwon
Changes in Pressure, Hemodynamics and Metabolism Within the Spinal Cord During the First 7-days After Injury Using a Porcine Model
RJournal of Neurotrauma. August 2017

Laure Penard, Karsten Skydsgaard, Christophe Bory, Edward Marsden
Challenges of intravenous infusion in the juvenile beagle dog
Reproductive Toxicology Volume 72, September 2017, Pages 46

C. Laloux, F. Gouel, C. Lachaud, K. Timmerman, B. Do Van, A. Jonneaux, M. Petrault, G. Garcon, N. Rouaix, C. Moreau, R. Bordet, J.A. Duce, J.C. Devedjian, D. Devos
Continuous cerebroventricular administration of dopamine: A new treatment for severe dyskinesia in Parkinson's disease?
Neurobiology of Disease

Robert Andersson, Tobias Kroon, Joachim Almquist, Mats Jirstrand, Nicholas D. Oakes, Neil D. Evans, Michael J. Chappel, Johan Gabrielsson
Modeling of free fatty acid dynamics: insulin and nicotinic acid resistance under acute and chronic treatments
J Pharmacokinet Pharmacodyn | DOI 10.1007/s10928-017-9512-6 Accepted: 7 February 2017

Masayuki Nakano, Yasuhisa Tamura, Masanori Yamatox, Satoshi Kume, Asami Eguchi, Kumi Takata, Yasuyoshi Watanabe & Yosky Kataoka
NG2 glial cells regulate neuroimmunological responses to maintain neuronal function and survival
Scientific Reports | 7:42041 | DOI: 10.1038/srep42041 Published: 14 February 2017

Kroon T, Baccega T2, Olsén A, Gabrielsson J, Oakes ND
Nicotinic acid timed to feeding reverses tissue lipid accumulation and improves glucose control in obese Zucker rats[S].
J Lipid Res. 2017 Jan;58(1):31-41. doi: 10.1194/jlr.M068395. Epub 2016 Nov 15.

Hasan M. Zahid, MohammedZubaerul Ferdaus, HirokiOhara, Minoru Isomura & Toru Nabika
Effect of p22phox depletion on sympathetic regulation of blood pressure in SHRSP: evaluation in a new congenic strain
Scientific Reports | 6:36739 | DOI: 10.1038/srep36739 Published: 08 November 2016

Rongwei Li, Kang Ma, Hengli Zhao, Zhou Feng, Yang Yang, Hongfei Ge, Xuan Zhang, Jun Tang, Yi Yin, Xin Liu, Liang Tan & Hua Feng
Cattle encephalon glycoside and ignotin reduced white matter injury and prevented post-hemorrhagic hydrocephalus in a rat model of intracerebral hemorrhage
Scientific Reports | 6:35923 | DOI: 10.1038/srep35923, 26 October 2016

Helge Thisgaard, Bo Halle, Charlotte Aaberg-Jessen, Birgitte Brinkmann Olsen, Anne Sofie Nautrup Therkelsen, Johan Hygum Dam, Niels Langkjær, Sune Munthe, Kjell Någren, Poul Flemming Høilund-Carlsen, Bjarne Winther Kristensen
Highly Effective Auger-Electron Therapy in an Orthotopic Glioblastoma Xenograft Model using Convection-Enhanced Delivery
Theranostics 2016, Vol. 6, Issue 12 2016; 6(12): 2278-2291. doi: 10.7150/thno.15898

Theodore A. Slotkin, Ashley Stadler, Samantha Skavicus, Jennifer Card, Jonathan Ruff, Edward D. Levin and Frederic J. Seidler
Is There a Critical Period for the Developmental Neurotoxicity of Low-Level Tobacco Smoke Exposure?
Toxicological Sciences 10.1093/toxsci/kfw180 Accepted September 6, 2016.

Tomonori Nakamura, Ikuhiro Okamoto, Kotaro Sasaki, Yukihiro Yabuta, Chizuru Iwatani, Hideaki Tsuchiya, Yasunari Seita, Shinichiro Nakamura,Takuya Yamamoto & Mitinori Saitou
A developmental coordinate of pluripotency among mice, monkeys and humans
Nature 537, 57–62 (01 September 2016) doi:10.1038/nature19096
Received 02 November 2015 Accepted 12 July 2016 Published online 24 August 2016

A. Maleah Holland, Michael D. Roberts, Petey W. Mumford, Christopher Brooks Mobley, Wesley C. Kephart, Christine F. Conover, Luke A. Beggs, Alexander Balaez, Dana M. Otzel, Joshua F. Yarrow, Stephen E. Borst, Darren T. Beck
Testosterone inhibits expression of lipogenic genes in visceral fat by an estrogen-dependent mechanism
Journal of Applied Physiology Published 18 August 2016 Vol. no. , DOI: 10.1152/japplphysiol.00238.2016

Vivi Flou Hjorth Jensen, Anne-Marie Mølck, Martin Mårtensson, Mette Aagaard Strid, Melissa Chapman, Jens Lykkesfeldt, Ingrid Brück Bøgh
Assessment of implantable infusion pumps for continuous infusion of human insulin in rats: potential for group housing
Lab Anim. 2016 Jul 27. pii: 0023677216660740. doi:10.1177/0023677216660740

Keisuke Shinohara, ToshimichiHata
Memory forgetting and NMDA receptor:Post-acquisition chronic microinfusionof NVP-AAM077 into dorsal hippocampus subsequently impairs the performance at reversal learning task in Morris water maze in rats
The 39thAnnual Meeting of the Japan Neuroscience Society, Oral Session Learning and Cognition: Hippocampus [O2-H-2-2] July 21, 2016

Steplewski A, Fertala J, Beredjiklian PK, Abboud JA, Wang MLY, Namdari S, Barlow J, Rivlin M, Arnold WV, Kostas J, Hou C, Fertala A
Blocking collagen fibril formation in injured knees reduces flexion contracture in a rabbit model
J Orthop Res. 2017 May;35(5):1038-1046. doi: 10.1002/jor.23369. Epub 2016 Jul 29.

Tobias Kroon
Optimizing Nicotinic Acid Delivery for Durable Antilipolysis and Improved Metabolic Control
Diss. (sammanfattning/summary) Uppsala : Sveriges lantbruksuniv., Acta Universitatis agriculturae Sueciae, 1652-6880 ; 2016:31 ISBN 978-91-576-8564-3 eISBN 978-91-576-8565-0

R. Croft Thomas, Jr., Patrick M. Cowley, Abhishek Singh, Bat-Erdene Myagmar, Philip M. Swigart, Anthony J. Baker, Paul C. Simpson
The Alpha-1A Adrenergic Receptor in the Rabbit Heart
PLOS ONE | DOI:10.1371/journal.pone.0155238 June 3, 2016

Toshiyuki Hamada, Kenneth Sutherland, Masayori Ishikawa, Naoki Miyamoto, Sato Honma, Hiroki Shirato & Ken-ichi Honma
In vivo imaging of clock gene expression in multiple tissues of freely moving mice
NATURE COMMUNICATIONS | 7:11705 | DOI: 10.1038/ncomms11705

Joshua S. Speed & Kelly A. Hyndman
In vivo organ specific drug delivery with implantable peristaltic pumps
Scientific Reports 6, Article number: 26251 (2016) doi:10.1038/srep26251

Yasunari Seita, Tomoyuki Tsukiyama, Chizuru Iwatani, Hideaki Tsuchiya, Jun Matsushita, Takuya Azami, Junko Okahara, Shinichiro Nakamura, Yoshitaka Hayashi, Seiji Hitoshi, Yasushi Itoh, Takeshi Imamura, Masaki Nishimura,Ikuo Tooyama, Hiroyuki Miyoshi, Mitinori Saitou, Kazumasa Ogasawara, Erika Sasaki & Masatsugu Ema
Generation of transgenic cynomolgus monkeys that express green fluorescent protein throughout the whole body
Scientific Reports | 6:24868 | DOI: 10.1038/srep24868

Mitchell D., Read, K., Chapman M. and Patten
Intrathecal administration using the iPRECIO® implanted pump
Development in Life Sciences, Vol 14, No. 4

Laura Gey, Manuela Gernert, Wolfgang Löscher
Continuous bilateral infusion of vigabatrin into the subthalamic nucleus : Effects on seizure threshold and GABA metabolism in two rat models
Neurobiology of Disease Volume 91, July 2016, Pages 194–208 doi:10.1016/j.nbd.2016.03.012

C. Bory, P. Lege, E. Chalencon, J.-P. Briffaux, and S. Milano. WIL Research Europe, Lyon, France.
Pilot Study Investigating the Pressor Activity of Vasopressin Infused by the Subcutaneously Implanted SMP-200 Microinfusion Pump in the Telemetered Rat.
Poster P446, Society of Toxicology55th Annual Meeting, New Orleans, United States, March 13th to 17th 2016.

E. Chalencon, C. Bory, J.-P. Briffaux, and S. Milano. WIL Research Europe, Lyon, France.
Hemodynamic Effects of Amlodipine Intravenously Infused for 6 Weeks by Implantable SMP-200 Microinfusion Pump in the Spontaneously Hypertensive (SH) Telemetered Rat.
Poster P448, Society of Toxicology 55th Annual Meeting, New Orleans, United States, March 13th to 17th 2016.

Donna Tan, Ajai Vyas
Toxoplasma gondii infection and testosterone congruently increase tolerance of male rats for risk of reward forfeiture
Hormones and Behavior 79 (2016) 37–44

Masaru Tsuboi,Yoshihide Ueda,Yasufumi Ota,Hiroshi Takehara,Takuya Aoshima,Fukutaro Mizuhashi
Physiological conditions in iPRECIO® -implanted rats
Fundamental Toxicological Sciences Vol.3 (2016) No.1 p.1-8

Bo Halle, Eric G. Marcusson, Charlotte Aaberg-Jessen, Stine S. Jensen, Morten Meyer, Mette K. Schulz, Claus Andersen, Bjarne W. Kristensen
Convection-enhanced delivery of an anti-miR is well-tolerated, preserves anti-miR stability and causes efficient target de-repression: a proof of concept.
Journal of Neuro-Oncology 2015 Oct 1.

T. Kroon, J. Gabrielsson, N.D. Oakes
The abruptness of terminating nicotinic acid delivery has a profound effect on free fatty acid and insulin rebound in rats
51st EASD Annual Meeting, Stockholm 2015

Christophe Bory, Philippe Legé, Estelle Chalencon, Stéphane Milano, WIL Research Europe Lyon, St Germain-Nuelles, France
Vasopressin pressor activity in telemetered rat infused with SMP 200 micro infusion pump. A pilot study
E-Posters: eP-54, 51st Congress of the European Societies of Toxicology, September 13th 2015

Estelle Chalencon, C. Bory and S. Milano
SMP-200 micro infusion pump: effect of 6-weeks intravenous treatment with Amlodipine in spontaneously hypertensive (SHR) telemetered rat
5th Infusion Technology Organization Meeting, September 7th-8th 2015, Cologne, Germany.

Laura Gey, W Löscher and M Gernert
Use of iPrecio implantable micro infusion pumps for targeted intracerebral drug delivery in a rat model of epilepsy
5th Infusion Technology Organization Meeting, September 7th-8th 2015, Cologne, Germany.

Christian Schnell
The harmony of gold standard physiological monitoring with novel infusion technology: Better quality of science in pre-clinical models ranging from mice to marmosets
5th Infusion Technology Organization Meeting, September 7th-8th 2015, Cologne, Germany.

K Drew, T Jinka, L Bogren, I Bailey, Z Carlson, J Olson
US Patent 20,150,238,513, 2015

Andreas Lundt, Carola Wormuth, Magdalena Elisabeth Siwek, Ralf Müller, Dan Ehninger, Christina Henseler, Karl Broich, Anna Papazoglou, and Marco Weiergräber
EEG radiotelemetry in small laboratory rodents - a powerful state-of-the art approach in neuropsychiatric, neurodegenerative and epilepsy research -
Neural Plasticity

Leigh J. Williams, Stephanie K. Klein, Danielle Greenawalt, Dawn Trueman, Helen Musgrove, Helen Jones, Linette Ruston, and Barry R. Davies
Establishment of an orthotopic bladder cancer model to evaluate continuous intravesical delivery of small molecule inhibitors in the nude rat
AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA

Tobias Kroon, Ann Kjellstedt, Pia Thalén, Johan Gabrielsson, Nicholas D. Oakes
Dosing Profile Profoundly Influences Nicotinic Acid's Ability to Improve Metabolic Control in Rats
The Journal of Lipid Research, doi: 10.1194/jlr.M058149 , July 13, 2015

Shanti Akers, Samuel GLickman, Serban A. Staicu, Deborah Haight, R. J. White
Increasing Dose Treprostinil and Tadalafil in Male Rats with Severe Pulmonary Hypertension
May 1, 2015,A1954-A1954

Tulasi Ram Jinka , Velva Combs , and Kelly L Drew
Translating drug-induced hibernation to therapeutic hypothermia
ACS Chem. Neurosci., March 26, 2015, DOI: 10.1021/acschemneuro.5b00056

Kohki Matsubara, Yoshihiro Matsushita, Kiyoshi Sakai, Fumiya Kano, Megumi Kondo, Mariko Noda, Noboru Hashimoto, Shiro Imagama, Naoki Ishiguro, Akio Suzumura, Minoru Ueda, Koichi Furukawa, and Akihito Yamamoto
Secreted Ectodomain of Sialic Acid-Binding Ig-Like Lectin-9 and Monocyte Chemoattractant Protein-1 Promote Recovery after Rat Spinal Cord Injury by Altering Macrophage Polarity
The Journal of Neuroscience, February 11, 2015 • 35(6):2452–2464

Kelly E. Henry, Clinton T. Elfers, Rachael M. Burke, Oleg G. Chepurny,George G. Holz, James E. Blevins, Christian L. Roth, Robert P. Doyle
Vitamin B12 Conjugation of Peptide-YY3–36 Decreases Food Intake Compared to Native Peptide-YY3–36 Upon Subcutaneous Administration in Male Rats
Endocrinology February 6, 2015 doi: 10.1210/en.2014-1825

David C. Irwina, Jin Hyen Baekb,Kathryn Hassellc, Rachelle Nussc, Paul Eigenbergera, Christina Liska, Zoe Loomisc, Joanne Maltzahna, Kurt R Stenmarkd, Eva Nozik-Grayckd, Paul W. Buehlera
Hemoglobin induced lung vascular oxidation, inflammation, and remodeling contributes to the progression of hypoxic pulmonary hypertension and is attenuated in rats with repeat dose haptoglobin administration
Free Radical Biology and Medicine doi:10.1016/j.freeradbiomed.2015.01.012

Hiroshi Nakamoto, Kazuhiko Nakayama, Noriaki Emoto, and Fumihiko Kajiya
The Short-Term Effects of C-Peptide on the Early Diabetes-Related Ultrastructural Changes to the Podocyte Slit Diaphragm of Glomeruli in Rats
Microcirculation DOI: 10.1111/micc.12185

Shobha N. Bhattachar, David M. Bender, Stephanie A. Sweetana, James A. Wesley
Discovery Formulations: Approaches and Practices in Early Preclinical Development
Discovering and Developing Molecules with Optimal Drug-Like Properties
AAPS Advances in the Pharmaceutical Sciences Series Volume 15, 2015, pp 49-94 Chapter 2, 27 Sep 2014

Roy J. Haskell, Kimberly A. Foster, Ching Kim Tye, Michael Morgen
Enabling Discovery Through Leveraging and Miniaturizing Pharmaceutical Principles and Processes
Discovering and Developing Molecules with Optimal Drug-Like Properties
AAPS Advances in the Pharmaceutical Sciences Series Volume 15, 2015, pp 95-140 Chapter 3, 27 Sep 2014

Marcos T. Kuroki, Gregory D. Fink, and John W. Osborn
Comparison of arterial pressure and plasma ANG II responses to three methods of subcutaneous ANG II administration [Open Access]
Vascular Biology and Microcirculation
01 SEP 2014

Key words: salt-sensitive hypertension, angiotensin II-salt Hypertension, Alzet Minipump, iPRECIO pump, plasma angiotensin II

Yamamoto A., Matsubara K., Kano F. and Sakai K.
Analysis of the Neuroregenerative Activities of Mesenchymal Stem Cells in Functional Recovery after Rat Spinal Cord Injury
Animal Models for Stem Cell Therapy
Methods in Molecular Biology Volume 1213, 2014, pp 321-328 Chapter 26 , 04 Aug 2014

Roth C.L, Clinton Elfers C., Henry K., Burke R. and Doyle R.P.
Testing the Vitamin B12 Dietary Pathway for Delivery of Peptide-YY
Endocrine Society's 96th Annual Meeting and Expo, June 21–24, 2014 – Chicago, United States.

Kuroki M.T. . , Gregory D. Fink , John W. Osborn
Comparison of arterial pressure and plasma AngII responses to three methods of subcutaneous AngII administration
American Journal of Physiology - Heart and Circulatory PhysiologyJul 2014, DOI: 10.1152/ajpheart.00922.2013

Intermittent, but Not Continuous Nicotinic Acid (NiAc) Infusion Preserves Plasma Free Fatty Acid (FFA) Lowering and Ameliorates Insulin Resistance in Obese Zucker Rats
American Diabetes Association 74th Scientific Session, , San Francisco, CA, June 13-17th 2014
Poster #1823-P

Naotaro Akiyama, MD, PhD; Tomomi Yamamoto-Fukuda, MD, PhD; Haruo Takahashi, MD, PhD
Influence of Continuous Negative Pressure in the Rat Middle Ear
The Laryngoscope , DOI: 10.1002/lary.24767

Kenji Suehiro, Yuka Nakamura, Shuai Xu, Youichi Uda, Takafumi Matsumura, Yoshiaki Yamaguchi, Hitoshi Okamura, Toshihide Yamashita & Yoshinori Takei
Ecto-domain phosphorylation promotes functional recovery from spinal cord injury
Scientific Reports 4,Article number:4972doi:10.1038/srep04972

Darren T. Beck Ph.D., Joshua F. Yarrow Ph.D., Luke A. Beggs M.S., Dana M. Otzel Ph.D., Fan Ye Ph.D., Christine F. Conover B.S., Julie R. Miller B.S., Alexander Balaez B.S., Sarah M. Combs B.S., Alicia M. Leeper B.S., Alyssa A. Williams B.S., Stephanie A. Lachacz B.S., Nigel Zheng Ph.D., Thomas J. Wronski Ph.D. and Stephen E. Borst Ph.D.
Influence of Aromatase Inhibition on the Bone Protective Effects of Testosterone
Journal of Bone and Mineral Research, 2014. DOI: 10.1002/jbmr.2265

Gey L, Gernert M, Löscher W
Chronic focal delivery of the antiepileptic drug vigabatrin into the subthalamic nucleus (STN) for epilepsy treatment
Deutsche Gesellschaft für Experimentelle und Klinische Pharmakologie und Toxikologie e.V. 80th Annual Meeting, April 1-3, Hannover, Germany.
Naunyn-Schmiedeberg's Arch Pharmacol (2014) 387 (Suppl1): S1-S113 (DOI 10.1007/s00210-014-0960-x)

Duncan Patten (Huntingdon Life Sciences, UK)
Use of iPRECIO implantable micro infusion pumps in rats
4th Infusion Technology Organization Meeting, May 8th-9th 2014, Harrogate, UK.

Christian R. Schnell (Oncology Research, Novartis, Switzerland)
Use of iPRECIO implantable micro infusion pumps in rats
4th Infusion Technology Organization Meeting, May 8th-9th 2014, Harrogate, UK.

Leigh Williams (Astrazeneca, UK)
Establishment of an orthotopic model of bladder cancer for evaluation of molecularly targeted agents; intravesical delivery.
4th Infusion Technology Organization Meeting, May 8th-9th 2014, Harrogate, UK.

Masanori Yamato, Yasuhisa Tamura, Asami Eguchi, Satoshi Kume, Yukiharu Miyashige, Masayuki Nakano, Yasuyoshi Watanabe, Yosky Kataoka
Brain Interleukin-1β and the Intrinsic Receptor Antagonist Control Peripheral Toll-Like Receptor 3-Mediated Suppression of Spontaneous Activity in Rats
Published: March 12, 2014 DOI: 10.1371/journal.pone.0090950 PLOS ONE Volume 9 Issue 3

Noriko Arai-Nunota, Masahide Mizobuchi, Hiroaki Ogata, Ai Yamazaki-Nakazawa, Chiaki Kumata, Fumiko Kondo, Nozomu Hosaka, Fumihiko Koiwa, Eriko Kinugasa, Takanori Shibata, Tadao Akizawa
Intravenous Phosphate Loading Increases Fibroblast Growth Factor 23 in Uremic Rats
Published: March 13, 2014 DOI: 10.1371/journal.pone.0091096 PLOS ONE Volume 9 Issue 3

Halle B., Marcusson E., Aaberg-Jessen C., Jensen S.S., Meyer M, Schulz M.K., Andersen C., Kristensen B.W.
Efficient microRNA inhibition in a highly invasive orthotopic glioblastoma model
4th Quadrennial Meeting of the World Federation of Neuro-Oncology
November 21-24, 2013, San Francisco, California

Chloride cotransporter KCC2 is essential to exercise-dependent recovery of spinal reflexes after SCI.
Neuroscience 2013, San Diego, USA. November 9th - 13th 2013

Intraparenchymal spinal cord microdialysis in unanaesthetized freely moving pigs following thoracic spinal cord injury
Neuroscience 2013, San Diego, USA. November 9th - 13th 2013

Stanley W.C., Cox,J.W., Asemu G., O’Connell K.A., Dabkowski E.R., Xu W., Ribeiro R.F.Jr., Shekar K.C., Hoag S.W., Rastogi S., Sabbah H.N., Daneault C., Rosiers, C.
Evaluation of Docosahexaenoic Acid in a Dog Model of Hypertension Induced Left Ventricular Hypertrophy
Journal of Cardiovascular Translational Research, September 2013, DOI: 10.1007/s12265-013-9511-y

Beier H.
Pharmacokinetic application of the iPRECIO pump
DSI User Group Meeting, Berlin, Germany; March 21st & 22nd 2013

Imai T., Nakata E., Inoue K.
Inhibition of P2X4 receptor on spinal microglia attenuates mechanical allodynia in experimental autoimmune neuritis rats
Pain Research, Vol. 26 2011, O-59

Asemu G., O’Connell K.A., Cox J.W., Dabkowski E.R., Xu W., Ribeiro R.F. Jr., Shekar K.C., Hecker P.A. Rastogi S., Sabbah H.N., Hoppel C.L., and Stanley W.C.
Enhanced Resistance to Permeability Transition in Interfibrillar Cardiac Mitochondria in Dogs: Effects of Aging and Long Term Aldosterone Infusion
Am J Physiol Heart Circ Physiol ajpheart.00674.2012; published ahead of print December 15, 2012, doi:10.1152/ajpheart.00674.2012

Zaretsky D.V., Zaretskaia M.V., Durant P.J., Rusyniak D.E.
The use of microinfusion pump to perform intrahypothalamic injections in conscious rats.
Neuroscience 2012, New Orleans, USA., October 13th - 17 2012.

Patar, A., Jaafar, H., Jamalullail, S. M. S. S., & Abdullah, J. M.
The body wall crude extract of Stichopus variegatus promotes repair of acute contused spinal cord injury in rats by improving motor function and reduces intramedullary hemorrhage.
Biomed Res, 2012, 23(4), 483.22.

Sasaki N, Shinjo M, Hirakawa S, Nishinaka M, Tanaka Y, Mawatari K, Kitamori T, Sato K.
A palmtop-sized microfluidic cell culture system driven by a miniaturized infusion pump.
Electrophoresis. 2012 Jul;33(12):1729-35. doi: 10.1002/elps.201100691.

Buehler PW, Baek JH, Lisk C, Connor I, Sullivan T, Kominsky D, Majka S, Stenmark KR, Nozik-Grayck E, Bonaventura J, Irwin DC.
Free hemoglobin induction of pulmonary vascular disease: evidence for an inflammatory mechanism.
Am J Physiol Lung Cell Mol Physiol. 2012 Aug;303(4):L312-26. Epub 2012 Jun 22.

Yoshinori T., Kenji S., Kazuharu S., and Gozoh T.
Extracellular phosphorylation is a novel target for regenerative medicine against spinal cord injury. The FASEB Journal.

Malicdan MC, Noguchi S, Tokutomi T, Goto Y, Nonaka I, Hayashi YK, and Nishino I.
Peracetylated N-acetylmannosamine, a synthetic sugar molecule, efficiently rescues muscle phenotype and biochemical defects in mouse model of sialic acid-deficient myopathy.
J Biol Chem. 2012 Jan 20; 287(4):2689-705. Epub 2011 Dec 8

Perron J., Frenette V., and Copeman C.
Validation and use of the iPRECIO® Micro Infusion Pump on GLP studies
Society of Toxicology Annual Meeting, San Francisco, United States, March 11th to 14th 2012.

Copeman C, Perron J., Trudel Y., Caron S., Emond F., Frenette, and Burr M.
Intraputamenal Infusion in the albino rat
Society of Toxicology Annual Meeting, San Francisco, United States, March 11th to 14th 2012.

Wood S.K., McFadden D.V., Grigoriadis D., Bhatnagar S. and Valentino R.J.
Depressive and cardiovascular disease co-morbidity in a rat model of social stress: a putative role for corticotropin-releasing factor
Psychopharmacology 2012 Feb 10. [Epub ahead of print]

Imai T., Nakata E., Inoue K.
Inhibition of P2X4 receptor on spinal microglia attenuates mechanical allodynia in experimental autoimmune neuritis rats
Pain Research, Vol. 26 2011, O-59 Accepted: 7 February 2012

Clarke I.J., Smith J.T., Henry B.A., Oldfield B.J., Stefanidis A., Millar R.P., Sari I.P., Chng K., Fabre-Nys C., Caraty A., Ang B.T., Chan L., and Fraley G.S.
Gonadotropin-Inhibitory Hormone Is a Hypothalamic Peptide That Provides a Molecular Switch between Reproduction and Feeding.
Neuroendocrinology (DOI: 10.1159/000332822) First published online January 25, 2012.

Kusanagi A., Yamasaki J., Iwatani C., Tsuchiya H. and Torii R.
Reproduction, Fertility and Development 24(1) 222-222

Iwatani C., Yamasaki J., Kusanagi A., Tsuchiya H. and Torii R.
127 Ovarian stimulation in cynomolgus monkeys by a controlled release of follicular-stimulating hormone utilizing a micro infusion pump.
Reproduction, Fertility and Development 24 (1) 176-176

Patricia V Turner, Cynthia Pekow, Mary Ann Vasbinder, and Thea Brabb
Administration of Substances to Laboratory Animals: Equipment Considerations, Vehicle Selection, and Solute Preparation [Open Access]
J Am Assoc Lab Anim Sci. 2011 September; 50(5): 614–627. Published online 2011 September.

Patricia V Turner, Thea Brabb, Cynthia Pekow, and Mary Ann Vasbinder
Administration of Substances to Laboratory Animals: Routes of Administration and Factors to Consider [Open Access]
J Am Assoc Lab Anim Sci. 2011 September; 50(5): 600–613. Published online 2011 September.

Tsung Tan, Stephanie W. Watts, and Robert Patrick Davis
Drug Delivery: Enabling Technology for Drug Discovery and Development. iPRECIO® Micro Infusion Pump: Programmable, Refillable, and Implantable [Open Access]
Front Pharmacol. 2011; 2: 44. Published online 2011 July 29. doi: 10.3389/fphar.2011.00044

Key words: drug delivery, mini pump, osmotic pumps, implantable pump, dose response, quantitative pharmacology, preclinical, telemetry

Osborn J., presenter; Fink G., discussant
Implantable infusion pumps for chronic rodent studies.
Workshop: Rodent Instrumentation Workshop M. Knuepfer, Experimental Biology, Washington DC.; April 9th to 13th 2011

Yoshinori T.,
Extracellular protein phosphorylation promotes functional recovery from experimental spinal cord injury.
The 6th International Symposium on Receptor Mechanisms, Signal Transduction and Drug Effects
- Development of Novel Therapy to Specific Disease in organ -, Kyoto, Japan; April 1st and 2nd 2011

Schnell C. and Ferrat T.,
Use of novel programmable pump for intracranial administration in an orthotopic glioblastoma tumor model in rats.
DSI User Group Meeting, Paris, France; March 17th 18th 2011

Martel E.
Refined rat pharmacology studies with infusion using implantable pumps.
DSI User Group Meeting, Paris, France; March 17th 18th 2011

Douglas G., Jones H., Edgington A., Saunders K., Neil Morgan S, Pullen N and Parenty G.
GPR54 agonists a way forward for downregulation of the GnRH pathway?
10th International Symposium on GnRH, Salzburg, Austria, Feb 6th -8th 2011

Shobo M., Yamada H., Koakutsu A., Hamada N., Fujii M, Harada K., Ni K., and Matsuoka N.,
Chronic treatment with olanzapine via a novel infusion pump induces adiposity in male rats.
Life Sciences, Volume 88, Issues 17–18, 25 April 2011, Pages 761-765 []

Chikara Abe, Kunihiko Tanaka, Chihiro Iwata, and Hironobu Morita
Vestibular-mediated increase in central serotonin plays an important role in hypergravity-induced hypophagia in rats
J Appl Physiol, 2010 Sep 16 [Epub ahead of print]; [PubMed Link]

Yamato M., Okuyama K., Jin GH., Eguchi A., Watanabe Y., Kataoka Y.
Endogenous IL-1β and IL-1 receptor antagonist in the brain are involved in poly I:C-induced immunological fatigue
The 33rd Annual Meeting of the Japan Neuroscience Society, Kobe, Japan., September 2nd – 4th 2010.

Stephanie W. Watts
The Evolving Story of 5-HT and Blood Pressure Mechanisms in a Muddle
Serotonin Club 2010, Montreal, Canada, July 9-11 2010

Susan K. Wood
Insights into pharmacotherapy for co-morbid depression and cardiovascular disease using a rodent model of social stress
iPRECIO® Luncheon Seminar, EB2010, Anaheim, United States, April 20-24 2010

Patrick Davis, Gregory D Fink, Bridget Seitz, and Stephanie W Watts
Serotonin infusion via the iPrecio® micro infusion pump results in repeated reductions in blood pressure in the normotensive Sprague Dawley rat.
FASEB J. 2010 24:lb551 [Abstract in the FASEB Journal]

Jay Gizzi, Theodore Baird, Kyle O'Donohue, Josh Yoder, Jessica Grenwis, and Heather Bogie
Optimization of a fully implantable small animal infusion model involving multi-pressure data collection.
FASEB J. 2010 24:lb571 [Abstract in the FASEB Journal]

Shobo M., Yamada H., Koakutsu A., Harada K., Ni K., and Matsuoka N.
Effect of long-term electrical infusion of olanzapine on fat weight in rats: a novel method for administration of biologically and/or chemically fragile compounds.
The 83rd Annual Meeting of the Japanese Pharmacological Society, Osaka, Japan, March 16th -18th 2010

Abe C., Tanaka K., Awazu H., Morita H.
The role of the vestibular system on the metabolism under hypergravity environment in rats: Implication for motion sickness.
Neuroscience 2009, Chicago, USA., October 17th - 21st 2009.

Yamato M., Okuyama K., Jin GH., Eguchi A., Watanabe Y., Kataoka Y.
Interleukin-1 β expression in the brain is involved in poly I:C-induced immunological fatigue-like behavior in rats
The 32nd Annual Meeting of the Japan Neuroscience Society, Nagoya, Japan., September 16th - 18th 2009.

Coles D.I., Warr A., Mead A.
Characterization of Pentobarbital Physical Dependance and Withdrawal in Rats
9th. Safety Pharmacology Society Annual Meeting, Strasbourg, France., September 15th - 18th 2009.

Infusion Pumps for Small Laboratory Animals
ALN Magazine May/June 2009

Iwatani C., Yamasaki J., Okahara-Narita J.,Tsuchiya H., Torii R.
Research Center for Animal Life Science Shiga University of Medical Science
Follicular stimulation with micro infusion pump in cynomolgus monkeys (Macaca fascicularis)
The 56th Annual Meeting of the Japanese Association for Laboratory Animal Science 2009, Omiya Sonic City, Japan., May13th - 16th 2009.

Abe C, Tashiro T, Tanaka K, Ogihara R, Morita H.
A novel type of implantable and programmable infusion pump for small laboratory animals.
J Pharmacol Toxicol Methods. 2008 Sep 22. [PubMed Link]

Emiko Matsuoka, Makoto Miyazaki, Kazunori Iwanaga, and Masao Kakemi.
Assessment of Pharmacokinetic-Pharmacodynamic Relationship of Vitamin B12 in the Treatment of Somnipathy in Rats
14th Annual Meeting of Japanese Society for Chronobiology, Tokyo, Japan, November 7-9 2007

You can request for our support materials of your interest from our contact us page from this website.

Page top

Privacy Policy