Innovative drug infusion technology for laboratory animals.

Support Materials of iPRECIO®      

You can request for our support materials of your interest from our contact us page from this website.

Support Documents and Technical Notes   Bibliography   

Support Documents and Technical Notes

Compatibility test <Compatible solvents/vehicles for iPRECIO>

You can request for our support materials of your interest from our contact us page from this website.

Application Note : Animal Body Weight and Strain

Guidance for animal weight and strain information for implanting SMP-300 pumps.

Technical Note : Performance of the iPRECIO® Pumps

Flow infusion accuracy of iPRECIO pumps (in-vitro testing).

Application Guide : Angiotensin II Infusion with SMP-300 in Mice with Blood Pressure Monitoring

Angiotensin II Infusion with SMP-300 in Mice with DSI PhysioTel®PA-C10 Blood Pressure Telemetry.

Technical Note : Recommendation for Intravenous Administration

This technical note outlines best practice implantation for iPRECIO pumps for long term continuous administration.

*Includes recommendation of catheters and couplers.

Technical Note : Recommendations for Subcutaneous Administration

This technical note defines best practice subcutaneous infusion administration site and iPRECIO pump placement and implantation.

Technical Note : Recommendations for Intraperitoneal Administration

This technical note defines best practice intraperitoneal infusion administration site and iPRECIO pump placement and implantation.

Technical Note : Recommendations for Intracerebral Administration

This technical note defines best practice intracerebral infusion administration site and iPRECIO pump placement and implantation. Cranial Infusion Kit for iPRECIO ® pump are supplied by Plastics One ® (

Technical Note : Materials Compatibility Kit for iPRECIO® Pump

This technical note defines the Standard Operating Procedure (SOP) for evaluating the compatibility of vehicle/solvents and agents to iPRECIO®.

Technical Note : SOPs for flow validation of iPRECIO® pumps

This technical note defines the Standard Operating Procedure (SOP) for flow accuracy validation based on residual/remaining solution in iPRECIO pumps.

Frequently Asked Questions <FAQ>

This FAQ incorporates the most frequent question and answers for iPRECIO pumps.

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Rodrigues, Marinelle, et al.
Susceptible bacteria “can” survive antibiotic treatment in the mammalian gastrointestinal tract without evolving resistance.
Cell Host & Microbe (2024).

Keywords: antibiotic resistance, antibiotic persistence, antibiotic tolerance, mammalian GI tract, bacterial survival, Escherichia coli, bacterial virulence

Mulla, Yuval, and Tobias Bollenbach.
Invade to evade: E. coli’s gutsy survival strategies.
Cell Host & Microbe 32.3 (2024): 300-301.
(Related to Rodrigues, Marinelle, et al. (2024))

Keywords: antibiotic resistance, in-vivo

An, Le, et al.
Early Stage Preclinical Formulation Strategies to Alter the Pharmacokinetic Profile of Two Small Molecule Therapeutics. [Open Access]
Pharmaceuticals 17.2 (2024): 179.

Keywords: drug delivery; PO; IV infusion; IP; SC; small molecule; PK profile; exposure

Devlin MacKeigan et al.
Chronic intermittent convection-enhanced delivery of vigabatrin to the bilateral subthalamic nucleus in an acute rat seizure model. [Open Access]
Epilepsy Research 199 (2024): 107276.

Keywords: Basal ganglia; Epilepsy; GABA transaminase Intracerebral pharmacotherapy; Pentylenetetrazole Tolerance

Tochinai, Ryota, et al.
Ivabradine ameliorates cardiomyopathy progression in a Duchenne muscular dystrophy model rat. [Open Access]
Experimental Animals (2023): 23-0087.

Key words: dystrophin deficiency, echocardiography, HCN channel, heart, tachycardia

A. COSTELLO, et al.
Modulatory effects of orexin/hypocretin on sleep/wakefulness, anhedonia, and neuroinflammation in a diurnal rodent model of Seasonal Affective Disorder.
Washington, D.C.: Society for Neuroscience, 2023. Online. Presentation Number PSTR043.12!/10892/presentation/34097

Key words: sleep, wakefulness, anhedonia, seasonal disorder

Lataro, Renata M., et al.
P2X3 receptor antagonism attenuates the progression of heart failure. [Open Access]
Nature Communications 14.1 (2023): 1725.

Moigneu, Carine, et al.
Systemic GDF11 attenuates depression-like phenotype in aged mice via stimulation of neuronal autophagy. [Open Access]
Nature Aging (2023): 1-16.

Saito, Tomohiro, et al.
Fibroblast Growth Factor 23 Exacerbates Cardiac Fibrosis in Deoxycorticosterone Acetate-Salt Mice With Hypertension. [Open Access]
Laboratory Investigation 103.1 (2023): 100003.

Key words: fibroblast growth factor 23, calcitriol, heart failure with preserved ejection fraction, transforming growth factor, cardiac fibrosis

Rodrigues, Marinelle, et al.
Susceptible bacteria survive antibiotic treatment in the mammalian gastrointestinal tract without evolving resistance. [Open Access]Preprint
bioRxiv (2023): 2023-01.

Reitz, Cristine J., et al.
A brief morning rest period benefits cardiac repair in pressure overload hypertrophy and post-myocardial infarction. [Open Access]
JCI insight (2022).

Key words: Cardiology

Manfredi-Lozano, Leysen et al.,
GnRH replacement rescues cognition in Down syndrome
Science 2022 Vol. 377 No. 6610, doi:10.1126/science.abq4515

Oliver, Jamie, and Mohamad Hussein.
P-110: Activity and tolerability of lenalidomide (LLD) is enhanced following low-dose continuous percutaneous delivery compared to once daily dosing in an NCIH929 MM Xenograft model in SCID mice.
Clinical Lymphoma, Myeloma and Leukemia 22 (2022): S95-S96.

Weiss, Andreas, et al.
Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C. [Open Access]
Cancer Discovery (2022): OF1-OF18.

Hamada, Kazuko, et al.
The analysis of Period1 gene expression in vivo and in vitro using a micro PMT system.
Biochemical and Biophysical Research Communications 577 (2021): 64-70.

Giuseppe Galvani, Nicola Mottolese, Laura Gennaccaro, Manuela Loi, Giorgio Medici, Marianna Tassinari, Claudia Fuchs, Elisabetta Ciani & Stefania Trazzi
Inhibition of microglia overactivation restores neuronal survival in a mouse model of CDKL5 deficiency disorder
Journal of Neuroinflammation volume 18, Article number: 155 (2021)

Key words: CDKL5, Neuroinflammation, Neuronal survival & Luteolin

Leon Teo, Anthony G. Boghdadi, Jihane Homman-Ludiye, Inaki-Carril Mundinano, William C. Kwan, James A. Bourne
Replicating infant-specific reactive astrocyte functions in the injured adult brain

Key words: Non-human primate, CNS injury, Eph/ephrin, Astrogliosis, Reactive astrocyte, Glial scarring

WO2020221821A1 Pulsative gnrh administration for treating cognitive disorders [Open Access] or

Marina BOROVINSKAYA, Fotios PLAKOGIANNIS, Nisarg MODI, Tamanna LATHAR, Rod L. Hartwig, James C. OLIVER
US20200330445A1 Continuous delivery of lenalidomide and other immunomodulatory agents
[Open Access]

See Example 1 or

Guilherme Dias de Melo, Florian Sonthonnax, Gabriel Lepousez, Grégory Jouvion ,Andrea Minola,Fabrizia Zatta, Florence Larrous, Lauriane Kergoat, Camille Mazo,Carine Moigneu, Roberta Aiello, Angela Salomoni, Elise Brisebard, Paola De Benedictis,D avide Corti & Hervé Bourhy
A combination of two human monoclonalantibodies cures symptomatic rabies [Open Access]
EMBO Mol Med (2020)e12628

Key words: immunetherapeutics, monoclonal antibody therapy, neglected diseases, neuroinfectious diseases, rabies virus

Wei Cao, Liling Wu, Xiaodong Zhang, Jing Zhou, Jian Wang, Zhichen Yang, Huanjuan Su, Youhua Liu, Christopher S. Wilcox and Fan Fan Hou
Sympathetic Overactivity in CKD Disrupts Buffering of Neurotransmission by Endothelium-Derived Hyperpolarizing Factor and Enhances Vasoconstriction
Jounarl of the American Society of Nephrology
JASN July 2020, ASN.2020030234; doi. :10.1681/ASN.2020030234

Topics: chronic kidney disease, hypertension, neurovascular transmission, sympathetic nervous system, connexin 43

Maxim Shevtsov, Susanne Kaesler, Stefan Stangl, Luidmila Yakovleva, Ruslana Tagaeva, Yaroslav Marchenko, Boris Nikolaev, William Khachatryan, Oleg Galibin, Emil Pitkin, Gabriele Multhoff.
Granzyme B functionalized nanocarriers targeting membrane-bound Hsp70 for multimodal cancer therapies [abstract].
In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 2878.

Anthony H Tsang, Christiane E Koch, Jana-Thabea Kiehn, Cosima X Schmidt, Henrik Oster
An adipokine feedback regulating diurnal food intake rhythms [Open Access]
RESEARCH ARTICLE Jul 9, eLife 2020;9:e55388 DOI: 10.7554/eLife.55388


Abe, C., Yamaoka, Y., Maejima, Y. et al.
VGLUT2-expressing neurons in the vestibular nuclear complex mediate gravitational stress-induced hypothermia in mice. [Open Access]
Commun Biol 3, 227 (2020)

Subjects: Neurophysiology, Stress and resilience

Jiro Kasahara, Masatoshi Ogawa, Yu Zhou, Ryosuke Tsuji, Satoshi Goto
Effects of intrastriatal memantine infusion in a mouse model of hemiparkinsonism
Proceedings for The 93rd Annual Meeting of the Japanese Pharmacological Society, 3-O-104 Oral Sessions

Emilia M. Lefevre, Marc T. Pisansky, Carlee Toddes, Federico Baruffaldi, Marco Pravetoni, Lin Tian, Thomas J. Y. Kono & Patrick E. Rothwell
Interruption of continuous opioid exposure exacerbates drug-evoked adaptations in the mesolimbic dopamine system
Neuropsychopharmacology (2020) | Published: 20 February 2020

Masatoshi Ogawa, Yu Zhou, Ryosuke Tsuji, Jiro Kasahara and Satoshi Goto
Intrastriatal Memantine Infusion Dampens Levodopa-Induced Dyskinesia and Motor Deficits in a Mouse Model of Hemiparkinsonism [Open Access]
Front. Neurol., 05 December 2019 | doi.: 10.3389/fneur.2019.01258

Key words: intracerebral brain infusion, levodopa-induced dyskinesia, memantine, N-methyl-D-aspartate receptor, Parkinson's disease

Yukitomo Arao, Katherine J. Hamilton, San-Pin Wu, Ming-Jer Tsai, Francesco J. DeMayo, and Kenneth S. Korach
Dysregulation of hypothalamic-pituitary estrogen receptor α–mediated signaling causes episodic LH secretion and cystic ovary

Maxim Shevtsov, Stefan Stangl, Boris Nikolaev, Ludmila Yakovleva, Yaroslav Marchenko, Ruslana Tagaeva, Wolfgang Sievert, Emil Pitkin, Anton Mazur, Peter Tolstoy, Oleg Galibin, Vyacheslav Ryzhov, Katja Steiger, Oleg Smirnov, William Khachatryan, Kerry Chester, and Gabriele Multhoff
Granzyme B Functionalized Nanoparticles Targeting Membrane Hsp70-Positive Tumors for Multimodal Cancer Theranostics
Small 2019, 1900205, DOI: 10.1002/smll.201900205

Martin F. Arlt Sountharia Rajendran Sandra N. Holmes Kathleen Wang Ingrid L. Bergin Samreen Ahmed Thomas E. Wilson Thomas W. Glover
Effects of hydroxyurea on CNV induction in the mouse germline
Environmental and Molecular Mutagenesis, 15 September 2018

J. Teixeira, N. Pires, B. Igreja, A. Loureiro, T. Vasconcelos, R. Lima, P. Soares-da-Silva
Evaluation And Comparison Of Drug Disposition Using Iprecio® Pumps In A Single And Prolonged Infusion (P549)
2018 Control Release Society Annual Meeting & Exposition, New York, July 22-24 2018!/5717/presentation/13652

Khalil B. Ramadi, Canan Dagdeviren, Kevin C. Spencer, Pauline Joe, Max Cotler, Erin Rousseau, Carlos Nunez-Lopez, Ann M. Graybiel, Robert Langer, and Michael J. Cima
Focal, remote-controlled, chronic chemical modulation of brain microstructures
PNAS July 10, 2018 115 (28) 7254-7259; published ahead of print June 25, 2018

Stefania Trazzi Marianna De Franceschi Claudia Fuchs Stefano Bastianini Rocchina Viggiano Leonardo Lupori Raffaele Mazziotti Giorgio Medici Viviana Lo Martire Elisa Ren Roberto Rimondini Giovanna Zoccoli Renata Bartesaghi Tommaso Pizzorusso Elisabetta Cian
Human Molecular Genetics, ddy064, 20 February 2018

Canan Dagdeviren, Khalil B. Ramadi, Pauline Joe, Kevin Spencer, Helen N. Schwerdt,Hideki Shimazu, Sebastien Delcasso, Ken-ichi Amemori,Carlos Nunez-Lopez, Ann M. Graybiel, Michael J. Cima, Robert Langer
Miniaturized neural system for chronic, local intracerebral drug delivery
Science Translational Medicine 24 Jan 2018: Vol. 10, Issue 425, eaan2742 DOI: 10.1126/scitranslmed.aan2742

Andreas Körner, Martin Schlegel, Julia Theurer, Hannes Frohnmeyer, Michael Adolph, Marieke Heijink, Martin Giera, Peter Rosenberger & Valbona Mirakaj
Resolution of inflammation and sepsis survival are improved by dietary Ω-3 fatty acids
Cell Death and Differentiation doi:10.1038/cdd.2017.177 20 October 2017

Mechanisms specific to methamphetamine-associated memory disruption by nonmuscle myosin II inhibition
420.01 / SS23, Neuroscience Annual Meeting 2017, Nov 11th to 15th 2017 Washington DC, United States!/4376/presentation/16699

JRising, Gail M.; Holmes, Sandra N.; Rajendran, Sountharia; Yanovich,Amber L.; Arlt, Martin F.; Glover, Thomas W.
An Improved Method of Implanting a Programmable Continuous Infusion Pump in Mice
AALAS Annual Meeting, October 15-19, 2017

João Teixeira, Teófilo Vasconcelos, Patrício Soares-da-Silva, Ricardo Lima
Drug delivery system characterization of a formulation delivered from an iPRECIO® microinfusion pump
World Congress of Pharmacy and Pharmaceutical Sciences 2017 (77th annual congress of FIP), Seoul, Republic of Korea, 10 - 14 September 2017

João Teixeira, Nuno Pires, Bruno Igreja, Ana Loureiro, Teófilo Vasconcelos, Ricardo Lima, Patrício Soares-da-Silva
Comparative bioavailability of a drug in a peg based solution using an iPRECIO® pump infusion and subcutaneous bolus
World Congress of Pharmacy and Pharmaceutical Sciences 2017 (77th annual congress of FIP), Seoul, Republic of Korea, 10 - 14 September 2017

João Teixeira, Nuno Pires, Bruno Igreja, Ana Loureiro, Teófilo Vasconcelos, Ricardo Lima, Patrício Soares-da-Silva
Comparative bioavailability of cyclodextrins’ based drug delivery from ALZET® and iPRECIO® pumps and subcutaneous bolus administration
World Congress of Pharmacy and Pharmaceutical Sciences 2017 (77th annual congress of FIP), Seoul, Republic of Korea, 10 - 14 September 2017

Kerry J. Trotter, Federico Buffaldi, Marco Pravetoni, Patrick E. Rothwell
Convergent and Divergent Behavioral Changes Caused by Different Patterns of Morphine Exposure in Mice
International Narcotics Research Conference (INRC), Chicago, 9 - 14 of July 2017

Alec Salt, Jared Hartsock, Ruth Gill, Daniel Smyth, Jonathon Kirk, Kristien Verhoeven
Perilymph pharmacokinetics of marker applied through a cochlear implant in guinea pigs
PLOS ONE | August 17, 2017

Hirotada Tajiri, Takehito Uruno, Takahiro Shirai, Daisuke Takaya, Shigeki Matsunaga, Daiki Setoyama, Mayuki Watanabe, Mutsuko Kukimoto-Niino, Kounosuke Oisaki, Miho Ushijima, Fumiyuki Sanematsu,Teruki Honma, Takaho Terada, Eiji Oki, Senji Shirasawa, Yoshihiko Maehara, Dongchon Kang, Jean-François Côté, Shigeyuki Yokoyama, Motomu Kanai, and Yoshinori Fukui
Targeting Ras-Driven Cancer Cell Survival and Invasion through Selective Inhibition of DOCK1
Cell Reports 19, 969–980, May 2, 2017

Yasuhiro Ogawa, Yoko Irukayama-Tomobe, Nobuyuki Murakoshi, Maiko Kiyama, Yui Ishikawa, Naoto Hosokawa, Hiromu Tominaga, Shuntaro Uchida, Saki Kimura, Mika Kanuka, Miho Morita, Michito Hamada, Satoru Takahashi, Yu Hayashi, Masashi Yanagisawa
Peripherally administered orexin improves survival of mice with endotoxin shock
eLife 2016;5:e21055. DOI: 10.7554/eLife.21055 Published December 30, 2016

Tsuyoshi Inoue, Chikara Abe, Sun-sang J. Sung, Stefan Moscalu,1 Jakub Jankowski, Liping Huang,Hong Ye, Diane L. Rosin, Patrice G. Guyenet, and Mark D. Okusa
Vagus nerve stimulation mediates protection from kidney ischemia-reperfusion injury through α7nAChR+ splenocytes
J Clin Invest. doi:10.1172/JCI83658 Published April 18, 2016

R.Sabharwal, L. Yang
Angiotensin-(1-7) Delays Onset of Dilated Cardiomyopathy in Mice with Muscular Dystrophy.
Poster B321 754.7, Experimental Biology (EB2016), San Diego, United States, April 2nd to 6th 2016

Rohit Chavan, Céline Feillet, Sara S. Fonseca Costa, James E. Delorme, Takashi Okabe, Jürgen A. Ripperger & Urs Albrecht
Liver-derived ketone bodies are necessary for food anticipation
Nature Communications 7, Article number: 10580 doi:10.1038/ncomms10580 Published 03 February 2016

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