Innovative drug infusion technology for laboratory animals.

Dobutamine, Saline and Verapamil Dose Response      

              *Click to enlarge each graph.

  • LV contractility was increased by successive doses of dobutamine; arterial systolic pressure was unaffected.
  • LV contractility and arterial systolic pressure were similarly decreased by administration of successive doses of verapamil.

Related Publications

Tan T., Watts S. W. and Davis R. P.
Drug delivery: enabling technology for drug discovery and development. iPRECIO Micro Infusion Pump: programmable, refillable, and implantable.
Front. Pharmacol. 2:44. doi: 10.3389/fphar.2011.00044

Jay Gizzi, Theodore Baird, Kyle O'Donohue, Josh Yoder, Jessica Grenwis, and Heather Bogie
Optimization of a fully implantable small animal infusion model involving multi-pressure data collection.
FASEB J. 2010 24:lb571

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