Christian Schnell's (Novartis Oncology) talk on "Challenges in enabling translation of tumor models in cancer therapy: Exploiting secreted luciferases to monitor tumor metastasis as a promising approach" at the Swiss 3Rs Day 2024 in the AGORA Cancer Research Centre in Lausanne. Recording sponsored by Primetech Corporation – makers of iPRECIO^® Programmable Pumps.

https://www.youtube.com/watch?v=7Tcdb4L3gCY

Sponsored 2024 3Rs Sharing Conference April 17, 2024
Genentech Campus, San Francisco, California
An in-person discussion-focused 3Rs conference hosted by the 3Rs Collaborative and the New Jersey Association for Biomedical Research.

Check out agenda https://3rc.org/3rs-sharing-conference/

Published: 30 January 2024 from Genentech, 1 DNA Way, South San Francisco,
An, Le, Tom De Bruyn, Jodie Pang, Savita Ubhayakar, Laurent Salphati, Xing Zhang, Liling Liu et al. "Early Stage Preclinical Formulation Strategies to Alter the Pharmacokinetic Profile of Two Small Molecule Therapeutics." Pharmaceuticals 17, no. 2 (2024): 179.
https://www.mdpi.com/1424-8247/17/2/179

Keywords: drug delivery; PO; IV infusion; IP; SC; small molecule; PK profile; exposure

Download and install our Latest Application Software for IMS/SMP-310R which was released in January 2024. Includes Release Notes. Go to our support page
https://www.iprecio.com/support/tabid/262/Default.aspx

6 new publications including 2 with STAR*METHODS (https://www.cell.com/cell/fulltext/S0092-8674(16)31072-8).
These two publications mention administrating clinically relevant doses.

Rodrigues, Marinelle, et al. "Susceptible bacteria “can” survive antibiotic treatment in the mammalian gastrointestinal tract without evolving resistance." Cell Host & Microbe (2024).
https://www.sciencedirect.com/science/article/abs/pii/S1931312824000167
Keywords: antibiotic resistance; antibiotic persistence; antibiotic tolerance; mammalian GI tract; bacterial survival; Escherichia coli; bacterial virulance

Giri, Tusar, et al. "Oxytocin Induced Birth Causes Sex Specific Behavioral and Brain Connectivity Changes in Developing Rat Offspring." Iscience (2024). https://www.sciencedirect.com/science/article/pii/S2589004224001810 [Open Access]
Subject areas: Endocrinology; Neuroscience; Behavioral neuroscience

7 new publications including Circadian and Pulsatile delivery.
See https://www.iprecio.com/support/tabid/196/Default.aspx and https://www.iprecio.com/support/tabid/161/Default.aspx for full details. Here are 3:-

Tochinai, Ryota, et al.
Ivabradine ameliorates cardiomyopathy progression in a Duchenne muscular dystrophy model rat. [Open Access]
Experimental Animals (2023): 23-0087.
https://www.jstage.jst.go.jp/article/expanim/advpub/0/advpub_23-0087/_article/-char/ja/
Key words: dystrophin deficiency, echocardiography, HCN channel, heart, tachycardia

Joshi, Pooja, et al.
Ryanodine receptor 2 inhibition reduces dispersion of cardiac repolarization, improves contractile function and prevents sudden arrhythmic death in failing hearts. [Open Access]
eLife 12 (2023)
https://elifesciences.org/reviewed-preprints/88638v2
Keywords: Sudden cardiac death (SCD), heart failure (HF), ventricular tachycardia/fibrillation (VT/VF)

Bering, Tenna, et al.,
Circadian Clock Genes Are Regulated by Rhythmic Corticosterone at Physiological Levels in the Rat Hippocampus.
Neuroendocrinology 113.10 (2023): 1076-1090.
https://karger.com/nen/article/113/10/1076/860659
Keywords: Clock gene, Corticosterone, Hippocampus, Programmable pumps, Suprachiasmatic nucleus

[Webinar] DATE: Wednesday, September 20, 2023
iPRECIO Micro Infusion Pump by Primetech Corporation sponsors Test Method Webinar. Learn about the webinar New Horizons: Gonadotropin-Releasing Hormone and Cognition by the joining Vincent Prevot, PhD as he dives into the development and establishment of the gonadotropin-releasing hormone (GnRH) system and the importance of its first postnatal activation. The webinar series Neurophysiology: Exploring Basic Research & Clinical Consequences is with the American Physiological Society, Society for Neuroscience, Federation of European Neuroscience Societies - FENS, and the American Autonomic Society! Webinar and related Scientific Publications details have been updated in our iPRECIO Application Booklet on page 23. Contact iPRECIO Micro Infusion Pumps by Primetech Corporation.

7 new publications: Four in Nature Aging (2023), Laboratory Investigation 103.1 (2023), Endocrinology 164.4 (2023) and Epilepsy Research (2023) respectively. 4 at preprint stage in bioRxiv (2023). See https://www.iprecio.com/support/tabid/196/Default.aspx and https://www.iprecio.com/support/tabid/161/Default.aspx for full details. Here are 2:-

Moigneu, Carine, et al. "Systemic GDF11 attenuates depression-like phenotype in aged mice via stimulation of neuronal autophagy." Nature Aging (2023): 1-16.
https://www.nature.com/articles/s43587-022-00352-3 [Open Access]

Hasegawa, Tomoka, et al. "Evocalcet Rescues Secondary Hyperparathyroidism-driven Cortical Porosity in CKD Male Rats." Endocrinology 164.4 (2023): bqad022.
https://academic.oup.com/endo/article/164/4/bqad022/7013989[Open Access]

Recent user/customer feedback; " Thank your company for developing this miniaturized programmable pump that has really been a game changer in this work (and promise to be of tremendous help in the field of Neuroendocrinology, Endocrinology and Metabolism in the future) and enabled the completion of preclinical studies in mice that paved the way to human clinical trials. "

Discovery and Characterization of JDQ443: a Structurally Novel Covalent Inhibitor of KRASG12C

Elizabeth McKenna, PhD, interviews Saskia Brachmann, PhD, Anna Farago, MD, PhD, and Andreas Weiss, PhD, about their paper describing a novel KRAS G12C inhibitor that was published concurrently with a Clinical Trials Minisymposium presentation at the 2022 AACR Annual Meeting. aacrjournals.org/cancerdiscovery/article/12/6/1500/699171
https://vimeo.com/720726054 iPRECIO SMP-310R Programmable pumps were used to better understand the relationship between PK, target occupancy, and efficacy.

[Webinar] "Discovery of JDQ443, a structurally novel, potent and selective covalent oral inhibitor of KRASG12C"; MedChemCASES #16: Dr. Simona Cotesta - " We describe the hit to lead and lead optimization by structure-based design of the novel chemical series leading to the discovery of NVP-JDQ443 (JDQ443), a novel, potent and selective, orally bioavailable KRASG12C covalent inhibitor. JDQ443 showed dose dependent antitumor efficacy in KRAS G12C-mutated cell-derived models and is currently in clinical development as monotherapy as well as in combination with TNO155, a SHP2 inhibitor (NCT04699188). " excerpt from https://www.gdch.de/netzwerk-strukturen/fachstrukturen/medizinische-chemie/veranstaltungen/medchemcases.html

dr Simona Cotesta (Novartis)
June 22, 2022
5:00 PM (Berlin time)
Registration link:https://us06web.zoom.us/webinar/register/WN_sgiCAfMKSISajiGRxoeb8w

iPRECIO SMP-310R Programmable pumps were used to better understand the relationship between PK, target occupancy, and efficacy.
" These findings demonstrate that antitumor activity can be achieved under both q.d. and b.i.d. dosing. To better understand the relationship between PK, target occupancy, and efficacy, a continuous infusion xenograft study was performed in the LU99 xenograft model and the PK/TO model applied to estimate the resulting levels of KRAS(G12C) target occupancy. " excerpt from publication, "Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRAS(G12C) Wiess et al. Cancer Discov OF1–OF18. https://lnkd.in/dikpP9Ej [Open Access]

Now all open access. No registration required: Compound Delivery, PK-PD, & Validation Studies in Oncology Research.
Slide deck, Expert Answers, Q&A Report, and On-demand Webinar< here >. Learn how Christian Schnell, Associate Director Oncology NIBR, Novartis Pharma AG, Basel, CH reached his conclusions.

Our iPRECIO Mouse pumps were mentioned by Jamie Oliver Chief Medical Officer of Starton Therapeutics at Precision Blood Cancer Symposium September 2021. Presentation available <here>

PhD fellowship in Circadian Neuroendocrinology in Copenhagen
https://employment.ku.dk/phd/?show=154989

“ Our lab facilities are located in central Copenhagen. Information on the department and our research group can be found at: https://in.ku.dk/research/rath-lab/ “

Your main task will be to perform stereotaxic surgeries in brains of rats in combination with circadian infusion of hormones, namely melatonin and cortisol, by use of programmable micropumps. You will subsequently analyse the circadian profile by telemetric and behavorial techniques.

Unprecedented PK-PD correlations in-Vivo Pharmacology Learn how Christian Schnell, Associate Director Oncology NIBR, Novartis Pharma AG, Basel, CH reached his conclusions. Now available on demand. Expert Answers, Q&A Report Slide Deck, and On-demand Webinar< here >.

Have you ever wanted to get more out of your in-vivo pharmaceutical studies? Have a burning question about programmable pumps and implication of refinement and reduction of animal use? Join Christian Schnell in his upcoming webinar on Programmable pumps for compounds delivery in oncology research: implication for refinement and reduction of animal use. More information and registration < here >

iPRECIO Programmable Minipumps for continuous delivery lenalidomide (LLD) in chronic lymphocytic leukemia (CLL). Video, https://youtu.be/d8CHR7et5zs from Start to 7 minutes: Rodent Studies of PK, Safety and Tolerability of LLD in Healthy and SCID Mice by Dr Jamie Oliver Chief Medical Officer of Starton Therapeutics (https://startontx.com/). IMS/SMP-300 for mice or larger used. Photo of SMP-200 for rats of larger shown.

New review article on iPRECIO^® - Linkedin Article – “Programmable pumps offer precise and translatable delivery of compounds to stress-free animals”
https://www.linkedin.com/pulse/programmable-pumps-offer-precise-translatable-delivery-tsung-tan/?trackingId=i9CxNGMbQJye6JF6HVLJSw%3D%3D

US20200330445A1: Continuous delivery of lenalidomide and other immunomodulatory agents
"After the tumor reached an average size of 100-150 mm, iPrecio pump was surgically implanted into each of the mice . Dosing began twenty - four hours post pump implantation. Each of Groups 3-6 was treated lenalidomide via continuous subcutaneous infusion at different hourly rate. The dosing lasted 14 days followed by one day off the treatment and lasted for another 14 days . The iPrecio pump was replaced after 14 days." For full reference: - Click -

IMS-200 version 13 Revision 532renew has been released
An important Application Software update has been released. Please contact us for downloading and installation instructions. Please share with us UCD-200 Serial Number. It can be found on the back of the programming device which plugs into the USB port of your PC. The upgrade is free and compatible with windows 10. Contact us <click here>

First introduced in July 19 2019 for mice, we are pleased to share that the first peer reviewed publication (JASN) referencing/using our IMS/SMP-310R has been published. “To study the effects of inhibiting central sympathetic outflow, groups of 5/6Nx mice received continuous intracerebroventricular (i.c.v.) infusions of clonidine (5.76 mg/kg per day) or artificial cerebral spinal fluid from the first day after operation for 4 weeks, using Micro Infusion Pumps (iPrecio SMP/IMS-310R model). “ Excerpt from Cao et al. - Sympathetic Overactivity in CKD Disrupts Buffering of Neurotransmission by Endothelium-Derived Hyperpolarizing Factor and Enhances Vasoconstriction. Click <here>.

Our Programmable iPRECIO minipumps used to administer humanized doses of antifungal. Advance Article Alert (August 1 2020) Journal of Antimicrobial Chemotherapy. Intermittent micafungin for prophylaxis in a rat model of chronic Candida albicans gut colonization [first study to administer humanized doses of antifungal treatment to rats via implantable iPRECIO pumps]
https://academic.oup.com/jac/article-abstract/doi/10.1093/jac/dkaa243/5877001.

Excerpt from publication: Pumps were pre-programmed to allow repeated infusion cycles of micafungin to simulate the expected systemic exposure of a human dose of 300mg every 72h or 55mg every 24h (Tables S1 and S2, available as Supplementary data at JAC Online).

Curious to learn more? Contact Primetech and ask us about trying out our IMS-200 Application Software <click here>

101 discreet infusion flow-rates and programmable infusions protocols (simple and complex)? Start all pumps simultaneously after recovery. Program starts and stops. Wondering how you would program this? Contact Primetech and ask us to have access to iPRECIO IMS-310R Group Profile or infusion < click here >. iPRECIO minipumps are the only programmable refillable and implantable drug delivery devices on the market.

Looking to be inspired? “Dreams and Perseverance” Prof Robert Langer -https://lnkd.in/fEANB9w. Co-organizer of US-JAPAN SYMPOSIUM ON DRUG DELIVERY SYSTEMS. You can also join him for a chat, COVID-19: A chat with Bob Langer on vaccines, nanotech & the future of healthcare. Details are here, https://us02web.zoom.us/webinar/register/2215869257189/WN_HISlJAjlTuu8yF2YC_P4VQ - #nanotech #the_future_of_healthcare hashtag #drugdelivery #drugdiscovery

101 discreet infusion flow-rates and programmable infusions protocols (simple and complex)? Wondering how you would program this? Contact Primetech and ask us to have access to iPRECIO IMS-310R Group Profile or infusion < click here >. iPRECIO minipumps are the only programmable refillable and implantable drug delivery devices on the market.

Important SMP-310R Product News.
0 to 10ul/hr pumps now available. For CE version : from SN 9X9001 and for FCC and IC from SN 9Y0001. Quick Comparison < here > and Summary 310R < here >.

iPRECIO^® for Mouse or larger – New Publication “Intrastriatal Memantine Infusion Dampens Levodopa-Induced Dyskinesia and Motor Deficits in a Mouse Model of Hemiparkinsonism” Excerpt - By using an intracerebral infusion system equipped with implantable, programmable, and refillable pumps, we show herein that continuous intrastriatal administration of memantine (MMT), which is a non-competitive N-methyl-D-aspartate receptor antagonist, attenuates levodopa-induced dyskinesias and parkinsonian signs in 6-hydroxydopamine-lesioned hemiparkinsonian mice that received daily levodopa treatment.

iPRECIO^® Micro Infusion Pumps was recently in the news <https://karger.altmetric.com/details/67351281/news>. “In this case, however, the researchers used the pump to emit carefully metered doses of corticosterone at different times of the day and night, similar to the animals' natural rhythm.” from <https://www.technologynetworks.com/tn/news/stress-hormone-helps-control-brain-cells-circadian-rhythm-327071>

Full publication can be found <https://www.karger.com/Article/Abstract/503720>.

Welcome Springer Nature readers!! We hope you will find our drug delivery offerings of interest. iPRECIO Application Tabular Highlights gives a high level view of how iPRECIO pumps were used/programmed in selected scientific publications in Applications Examples eBook <here>. The eBook gives more detailed information. e-mail Primetech for eBook. Quick overview of SMP-310R/300/200 <here>

You can find iPRECIO Micro Infusion Pumps on Booth 325 at AALAS2019 in Denver and Booth 842 & 904 at SFN2019 in Chicago.

IMS/SMP-310R Micro Infusion Pumps have been officially released and currently shipping for the US and Canada. Quick overview of SMP-310R/300/200 <here>. Note that specifications have been updated since last news. See full details for 310R <here>

Together with RRSSC (http://www.rrssc.eu/) Primetech organizes a course in iPRECIO pump implantation. Participants can choose between a 3-day course for basic implantation techniques or a 5-day course for more complicated techniques.

The 2nd course is planned from Sept 2-6. Please register directly with RRSSC; http://www.rrssc.eu/application-form.php.
Testimonials https://www.rrssc.eu/?s=iprecio

iPRECIO website has been updated with IMS/SMP-310R Micro Infusion Pumps. Release and shipping information to follow before the end of May 2019. Quick overview of SMP-310R/300/200 <here>. SMP-300 pumps have been discontinued but a limited number are still available for current users. Please <contact us> for more information.

Added to website. Tabular highlights gives a high level view of how iPRECIO pumps were used/programmed in selected scientific publications in Applications Examples eBook < here >.

Neuroscience 2018. iPRECIO Micro Infusion Pump on booth 2922. Ask us for our recently updated Example Applications & much more booklet for Neuroscience 2018 which summarizes data from peer reviewed articles and presentations. Preliminary 310R specifications published < here >.

United States Patent Application 20180161282 Methods and compositions for the treatment of seizure-related disorders by Adamas Biopharmaceutical Inc. (https://www.adamaspharma.com/) includes references to iPRECIO Micro Infusion Pump use in Examples 13 to 16. In example 13, “The PK parameters (Cmax, Tmax, T1/2, AUC) of 200 mg IR lacosamide BID and 400 mg ER lacosamide QD in humans can be replicated in rats using programmable subcutaneous infusion pumps. ”. For more information, see https://patents.google.com/ or http://appft.uspto.gov.

"The iPRECIO pump enables reliable, timed delivery of pharmacological agents. The pump was programmed for 1 hour delivery of Isoproterenol at 30ul/hr, total dose of 2mg/kg/day, once a day at the same time (1pm)” 4/5 week study duration.

Swati Dey et al., Mitochondrial ROS Drive Sudden Cardiac Death and Chronic Proteome Remodeling in Heart Failure Circulation Research. 2018;CIRCRESAHA.118.312708, originally published June 13, 2018 https://doi.org/10.1161/CIRCRESAHA.118.312708

RenaSci (http://www.renasci.co.uk/news/iprecio-micro-infusion-pumps) are now offering chronic administration of drugs via implantable, programmable, refillable, micro infusion iPRECIO^® pumps.

Experimental Biology iPRECIO Micro Infusion Pump on booth 936.
Learn how iPRECIO^™ Micro Infusion Pumps can make your research easier. Also, how our customers have been using our pumps, how we have helped them with their research goals and where they have been publishing. Also ask us for our recently updated Example Applications & much more booklet which summarizes data from peer reviewed articles and presentations.

Together with RRSSC (http://www.rrssc.eu/) Primetech organizes a course in iPRECIO pump implantation. Participants can choose between a 3-day course for basic implantation techniques or a 5-day course for more complicated techniques. Look <click here> for the program.

The first course is planned from June 11th to 15th 2018. Please register directly with RRSSC; http://www.rrssc.eu/application-form.php.

15^th publication with iPRECIO SMP-300 for drug delivery was published by researchers. Click <here> for references.

iPRECIO^® Micro Infusion Pumps was recently shown in the news, http://time.com/5118644/minds-brain-implant-remote-control/, https://www.dddmag.com/news/2018/01/tiny-implant-opens-way-deliver-drugs-deep-brain, https://www.aerzteblatt.de, …….
Full publication can be found < here >.

Neuroscience 2017 Annual Meeting iPRECIO Micro Infusion Pump on booth 918.
Learn how iPRECIO^® Micro Infusion Pumps can make your research easier. Also, how our customers have been using our pumps, how we have helped them with their research goals and where they have been publishing. Also ask us for our recently updated Example Applications & much more booklet for Neuroscience 2017 which summarizes data from peer reviewed articles and presentations.

The first PhD thesis where iPRECIO Micro Infusion Pumps were used. We are happy to have played our small part in their research. They used iPRECIO SMP-200 Micro Infusion Pumps for Optimizing Nicotinic Acid Delivery for Durable Antilipolysis and Improved Metabolic Control where a key principle of the work was the use of precisely defined plasma NiAc exposure profiles, produced using a programmable, implantable minipump.

Optimizing Nicotinic Acid Delivery for Durable Antilipolysis and Improved Metabolic Control
http://pub.epsilon.slu.se/13324/
http://pub.epsilon.slu.se/13324/1/kroon_t_160429.pdf

Together with RRSSC (http://www.rrssc.eu/) Primetech organizes a course in iPRECIO pump implantation. Participants can choose between a 3-day course for basic implantation techniques or a 5-day course for more complicated techniques. Look here for the program.
The first course is planned from April 24-28, 2017. Please register directly with RRSSC; http://www.rrssc.eu/application-form.php

We will exhibit iPRECIO^® at the Neuroscience 2016 Annual Meeting which is scheduled for November 12^th to 16^th at San Diego Convention Center. Drop by booth 3118 to see how iPRECIO^® Micro Infusion Pumps for mice and rats may be used to accelerate your research.

Based on audience feedback from our November 2015 webinar, Primetech has created a comprehensive resource package which includes:
   A summary of research applications featured in journals such as Nature Communications,
     Scientific Reports, Am J Physiol Heart, Journal of Lipid Research, Development in Life
     Sciences and Neurobiology of Disease
   Technical notes, SOPs and surgical training videos

Our first SMP-300 Micro Infusion Publication. We are happy to have played our small part in their research. They used iPRECIO SMP-300 Micro Infusion Pumps for timed release of ßOHB. Learn more at http://www.nature.com/ncomms/2016/160203/ncomms10580/full/ncomms10580.html

EB2016 April 2 - 6 2016, San Diego Convention Center, San Diego, CA , on booth 829.
Learn how iPRECIO^® Micro Infusion Pumps can make your research easier. Also, how our customers have been using our pumps, how we have helped them with their research goals and where they have been publishing. Also ask us for our Example Applications & much more booklet.

Learn how iPRECIO Micro Infusion Pumps will help you with your research needs.
Webinar recordings, slide decks, iPRECIO resources (Bibliography of Scientific publications by product features) and Q&A report are now all < Open Access > http://insidescientific.com/webinars/item/384-gold-standard-physiological-measurements-and-novel-drug-delivery-methods-iprecio.

We will exhibit iPRECIO^® at the Neuroscience 2015 Annual Meeting which is scheduled for October 17^th to 21^st at the McCormick Place in Chicago. Drop by booth 1657 to see how iPRECIO^® Micro Infusion Pumps for mice and rats may be used to accelerate your research.

Learn about how iPRECIO^®Micro Infusion Pumps have been used at the upcoming Infusion Technology Organization (ITO) Meeting. The 5^th ITO Meeting will be held on September 7/8, 2015 in Cologne, Germany. Programme may be found here, http://www.ito-org.eu/index.php?id=99 or directly here.

Surgical Training videos are available for SMP-300 for mice and SMP-200 for rats. Please contact Primetech to request access to the videos.

Solutions: Partners sought
A microinfusion pump drug delivery system to reduce animal use and refine studies
Primetech is seeking partners to help expand the use of their novel microinfusion pump for programmable infusion of test compounds in rats. The pump enables automated dosing, allowing the rats to move freely and minimising handling. The animals can also be group housed.

• Further information

We will exhibit iPRECIO^®at the Experimental Biology 2015 which is scheduled for March 28 - April 1 2015, Boston Convention and Exhibition Center, Boston, MA , on booth 225. Come and see our new pump, the iPRECIO SMP-300 for mice or larger.

Notocord and Primetech Corporation collaborate to release IPD30a for iPRECIO Dual Control with NOTOCORD-hem^™ Evolution for Europe. Find out more here: IPD30ab: iPRECIO^® Dual pump acquisition server and controller.

Contact us to get a copy of the following Scientific Publication:-

Milano S., Bory C., Lege P., Chalencon E., Gilbert K., Koeppel F.
Evaluation of iPRECIO^® – Dual Channel Pump: A Safety Pharmacology Study Case in the Cynomolgus Monkey
Safety Pharmacology Society Annual Conference, Rotterdam, The Netherlands, Sept 16th to 19th 2013

Bibliography Section updated.
New references were added to the bibliography section. These include publications in American Journal of Physiology - Heart and Circulatory Physiology, American Diabetes Association 74th Scientific Session and much more, [https://www.iprecio.com/support/]

We will exhibit iPRECIO^®at the Neuroscience 2014 Annual Meeting which is scheduled for November 15th to 19th 2014 in Washington DC at the Walter E. Washington Convention Center on booth 2619. Pick up our latest technology report and register to get new product news.

iPRECIO^® Dual Video has been added. Click here to see the new video. Don’t forget our Micro Infusion Pump videos for mice and rats.
You can see the SMP-300/IMS-300 (mice or larger) video: Click here.
You can see the SMP-200/IMS-200 (rats or larger) video: Click here.

We will exhibit iPRECIO^®at the Experimental Biology 2014 which is scheduled for April 26 -30 2014, San Diego Convention Center, San Diego, CA, on booth 624. Come and see our new pump, the iPRECIO SMP-300 for mice or larger.

SMP-300 iPRECIO^® video is now available. Click here to see new video.

Primetech Corporation has contracted Veterinary Bioscience Institute (VBI), www.vetbiotech.com, to develop comprehensive High Definition surgical training videos for iPRECIO^® Micro Infusion Pumps. VBI is the leading online and hands-on provider of surgical and methodology training and was founded in 2008. Check back in early 2014 to access surgical training videos or contact us if you would like to provide your input.

SMP-200 iPRECIO^® video has been updated. Click here to see new video. SMP-300 video will be available shortly.

Our Mission with iPRECIO^® Product Portfolio:-
1) Make it as easy as possible to evaluate efficacy of molecules/agents in different animal models and species.

2) Make the results as relevant as possible to the clinic. (Exposure profile, quantitative pharmacology, untethered free moving (stress free, group housing (socialization), ..…)

The use of iPRECIO^® pumps will have a positive impact on experimental conditions and the relevance of results achieved. Initial costs maybe higher but in the long run the use of the pump could be cost saving in the context of the whole compound development.

We will exhibit iPRECIO^®at the Neuroscience 2013 Annual Meeting which is scheduled for November 9th to 13th 2013 in San Diego at the San Diego Convention Center on booth 3118. Pick up our latest technology report and register to get new product news.

We will exhibit iPRECIO^®at the Experimental Biology 2013 which is scheduled for April 20 -24 2013, Boston Convention and Exhibition Center, Boston, MA, on booth 321.

Primetech welcomes Alzet^®Osmotic Pumps/Durect Corporation as an authorized iPRECIO^®Distributor in North America. Learn more about iPRECIO® Micro Infusion Pumps from Durect on www.alzet.com. Alzet^®Osmotic Pumps/Durect Corporation joins Data Sciences International (DSI) as our authorized distributor in North America.

Our Mission with iPRECIO^®SMP200 Micro Infusion Pump: (1) Make it as easy as possible to evaluate efficacy of molecules/agents in-vivo in different animal models and species and (2) Make the results as relevant as possible to the clinic. (Exposure profile, quantitative pharmacology , …)

We will exhibit iPRECIO^®at the Neuroscience 2012 Annual Meeting which is scheduled for October 13th to 17th 2012 in New Orleans at the Ernest N. Morial Convention Center on booth 2117. Pick up our latest technology report and register to get new product news.

Free Full text articles in Pub Med Central. Published 2011[Go to support materials page].

Bibliography Section updated.
New references were added to the bibliography section. These include publications in Neuroendocrinology and Psychopharmacology, [https://www.iprecio.com/support/]

We will exhibit iPRECIO^®at the Experimental Biology 2012 which is scheduled for April 22 -24 2012, San Diego Convention Center, San Diego, CA, on booth 1224.

iPRECIO^®Ambulatory Dual Inlet infusion pump for large animals was added to our website. Design of our website was updated.

The Drug Discovery Today sponsored webinar on Drug Delivery as enabling tool for drug discovery and drug development is now available on-demand. You can learn more or see the webinar by clicking here.

Register today for our Drug Discovery Today sponsored webinar on Drug Delivery as enabling tool for drug discovery and drug development. Ellis Meng of the University of Southern California will talk about the use of implantable devices for smart drug delivery and Eric Martel of CERB will talk about Refined rat pharmacology studies with infusion using implantable pumps. You can learn more or register by clicking here.

We will exhibit iPRECIO^®at the Neuroscience 2011 Annual Meeting which is scheduled for Nov. 12-16 in Washington DC at the Walter E Washington Convention Center on booth 2718. Please drop by and learn about what is new. Pick up our latest technology report and register to get new product news.

iPRECIO^®Technology Report has been published in Frontiers in Experimental Pharmacology and Drug Discovery an open-access publisher. The full report may be downloaded or read here.
Drug delivery: enabling technology for drug discovery and development.
Successful drug delivery using implantable pumps may be found in over 12,500 published articles. Their versatility in delivering continuous infusion, intermittent or complex infusion protocols acutely or chronically has made them ubiquitous in drug discovery and basic research.

Bibliography Section updated
5 new references were added to bibliography section
[https://www.iprecio.com/support/]

Chronic treatment with olanzapine via a novel infusion pump induces adiposity in male rats.
This finding was reported by Shobo et al. where Olanzapine concentrations at all times were higher and more stable than in any other reports. [Science Direct Link]

Technical Note 8, “Defines the best practice intrathecal infusion administration using iPRECIO® pumps with customized intrathecal catheter part number 0220 from Recathco (http://www.recathco.com/).“

Data Sciences International (DSI) releases case study on iPRECIO^®for 5-HT Administration. - This study demonstrated with an iPRECIO^®pump that a smaller rate of 5-HT than previously employed elicits a hypotensive effect in S.D. rats. Case study can be downloaded from the link, http://www.datasci.com/pdf/information/CaseStudy_MSU-iPRECIO%205HT.pdf

Technical Note 7, “Materials Compatibility Kit for iPRECIO® Pump” is now available. Standard Operating Procedure (SOP) for evaluating the compatibility of vehicle/solvents and agents to iPRECIO^®is described in detail.

We will exhibit iPRECIO^®at the Experimental Biology 2011 which is scheduled for April 9 -13 2011, Walter E. Washington Convention Center in Washington, DC on booth 931.

We will exhibit iPRECIO^®at the Neuroscience 2010 Annual Meeting which is scheduled for Nov. 13-17 in San Diego, CA at the San Diego Convention Center on booth 901.

See iPRECIO^®at the Safety Pharmacology Society 10th Annual Meeting which is scheduled for Sept. 20-23 in Boston, MA on booth 204 and 205. (Data Sciences International)

Data Sciences International (DSI) releases case study on iPRECIO^®for Ang II infusions where both Alzet^®and iPRECIO^®data are described. Case study can be downloaded from the link, http://www.datasci.com/pdf/information/CaseStudy_iPRECIO%20Comparison.pdf

Primetech will release Technical Note 6,
“Recommendations for Intracerebral Administration” at FENS 2010 (http://fens2010.neurosciences.asso.fr/), Amsterdam July 3^rd to 7^th 2010. Booth 342 Data Sciences International (DSI) and Booth 725 Linton Instruments ( Linton). 322OP: Starter Kit Cranial Infusion Kit for iPRECIO^®Pump and 322OP/Kit: Cranial Infusion Kit for iPRECIO^®pump are supplied by Plastics One^®(www.plastics1.com).

5-HT produces blood pressure lowering effect.
“The findings of this study are consistent with the initial hypothesis that 5-HT would produce a blood pressure lowering effect when the pump was turned on and blood pressure would return to normal when the pump was turned off. (0.2μl/hour) However, we did discover that instead of a dose response to 5-HT, we were able to achieve an equivalent effect at a much lower dose than had been previously studied.”
Robert Patrick Davis et al.; FASEB J. 2010 24:lb551