Davis et al. (Davis et al., 2010) previously established, using both the iPRECIO® micro infusion pump and radiotelemetry devices, that 5-HT administration produced repeated falls in blood pressure in the sham (normotensive) and deoxycorticosterone acetate (DOCA)-salt (hypertensive) rat when the pump was turned on. When the pump was turned off (0.2μl/hour), blood pressure returned to normal. This study demonstrated that an equivalent effect was possible at a much lower dose than was previously studied (25 µg/serotonin hydrochloride /kg/min) in the sham and DOCA-salt rat.

     

Related Publications

Tan T., Watts S. W. and Davis R. P.
Drug delivery: enabling technology for drug discovery and development. iPRECIO Micro Infusion Pump: programmable, refillable, and implantable.
Front. Pharmacol. 2:44. doi: 10.3389/fphar.2011.00044
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149148/


Jay Gizzi, Theodore Baird, Kyle O'Donohue, Josh Yoder, Jessica Grenwis, and Heather Bogie
Optimization of a fully implantable small animal infusion model involving multi-pressure data collection.
FASEB J. 2010 24:lb571
www.fasebj.org/cgi/content/meeting_abstract/24/1_MeetingAbstracts/lb571


Diaz J., Ni W., Thompson J., King A., Fink G.D., and Watts S.W.
5-Hydroxytryptamine Lowers Blood Pressure in Normotensive and Hypertensive Rats
JPET 325:1031–1038, 2008
http://www.ncbi.nlm.nih.gov/pubmed/18305011


Watts S.W., Morrison S.F., Davis, R.P., and Barman S.M.
Serotonin and Blood Pressure Regulation
Pharmacol Rev 64:359–388, 2012
http://pharmrev.aspetjournals.org/content/64/2/359.abstract