Tabular highlights gives a high level view of how iPRECIO pumps were used/programmed in selected scientific publications in Applications Examples eBook. For more detailed view, refer eBook and publications . In e-book for example, Research Application 1 (RA1) on page 5 & 6 of eBook is on row 1 of Tabular highlights – Chavan et al. The protocol is once a day infusion. RA2 on pages 7 & 8 (row 2 Kroon et al) has a 3 day stop prior to start of infusion of Nicotinic acid with the animal in the metabolic cage all of the time of the infusion protocol. For updated information and complete version, download PDF version.

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Research Application (RA) 1 - 6  GLP Studies with iPRECIO Pumps  Toxicology with iPRECIO Pumps  Application Examples (AP) 1 - 5  Webinar (WE)  Recently in the news

Research Application (RA)
Author, doi or www.			pg(s) number of eBook
Refillability of Pump		How pump programmed?
KVO/RCV	Vehicle and Drug(s)	Continuous	Intermittent or bolus	Circadian / Timed release
Adminstration Site		Duration
Key words
RA 1 Chavan et al. [doi:10.1038/ncomms10580]			pgs 5-6
1 week recovery	Pumps programmed to infuse saline (2ul/hr) or ßOHB (2ul/hr) or sodium pyruvate (5ul/hr) or coconut oil (5ul/hr) prior to meal time (6h, ZT22-ZT) in Restricted Food (RF)	No	Yes	Yes
SC		< 3 weeks
Biological sciences-Neuroscience-Biochemistry Mice + SMP-300 iPRECIO Pump
RA 2 Kroon et al. [doi:10.1194/jlr.M058149]			pgs 7-8
Pump programmed to stop for 3 days	Nicotinic Acid (NiAc) or saline 5 days of continuous or intermittent (12 hr ON/OFF cycles, infusion on 13:00h)	Yes	Yes	Yes
SC		5 or 11 days infusion + 2 days recovery
Adipose tissue-diabetes-drug therapy-Lipoysis and fatty acid metabolism-GPR109A-Niacin-Tachyphylaxis Zucker rat + SMP-200 Pump
RA 3 Suehiro et al. [doi:10.1038/srep04972]			pgs 9-10
No	PKA and ATP - solution change every 2 days, 1ul/hour	Yes	No	No
Intrathecal		14 days
Neural-stem cells-spinal cord injury, rat + SMP-200 Pump
RA 4 Mitchell et al. Developments in LifeSciences Vol. 14 No. 4 < link >			pgs 11-12
1ul/hr saline for 1 week for full recovery	Test articles infusing at 30ul/hr for 72 hours after 1ul/hr saline recovery after catherization and pump implantation	Yes	No	No
Intrathecal		10 days
Regulatory request, CNS end points (modified Irwin assessment), rat + SMP-200 Pump
RA 5 Asemu et al. [doi:10.1152/ajpheart.00674.2012]			pg 13
No	Aldosterone (15% ethanol 50% DMSO and 35% water) was continuous infused	Yes	No	No
IV jugular		14 weeks
Cardiac, diastolic dysfunction, heart failure, metabolism, dog + SMP-200 Pump
RA 6 Thisgaard et al. [doi:10.7150/thno.15898]			pg 14
No	Isotone saline, 0.1 mM MTX, then 0.3µg/ml 125I-UdR, 127I-UdR was continuously infused	Yes	No	No
Brain infusion		10 days
Glioblastoma, Auger-electron therapy, convection delivery, [125I]5-Iodo-2'-deoxyuridine, temozolomide, SMP-200 Pump

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GLP Studies with iPRECIO Pumps (page 15 eBook)
Author			pg(s) number of eBook
Refillability of Pump		How pump programmed?
KVO/RCV	Vehicle and Drug(s)	Continuous	Intermittent or bolus	Circadian / Timed release
Adminstration Site		Duration
Key words
Patten et al.			pg 15
1ul/hr artificial CSF	Treament period 30ul/hour for 72 hours	No	Yes	Yes
Intrathecal		3 days for TA
CNS (modified Irwin assessment), rat + SMP-200 pump
Perron et al.			pg 15
No	Flow-rate and dosing validation studies on the bench	No	Yes	Yes
in-vitro		< 7 days
GLP validation
Ringer et al.			pg 15
Saline when not infusing test article	2 hour baseline, 2 hour infusion (Milrinone or vehicle)	No	Yes	Yes
Right jugular vein		24 hours
GLP validation, jacktet, ambulatory, cardiovascular, Dog + iPRECIO Dual

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Toxicology with iPRECIO Pumps (page 15 eBook)
Author, doi:			pg(s) number of eBook
Refillability of Pump		How pump programmed?
KVO/RCV	Vehicle and Drug(s)	Continuous	Intermittent or bolus	Circadian / Timed release
Adminstration Site		Duration
Key words
Tsuboi et al. [doi:10.2131/fts.3.1]			pg 15
No but full study saline infusion	Saline infusion for 4 weeks and 13 weeks, 2 or 2.5ul/hour	Yes	No	No
IV jugular		4 or 13 weeks
Infusion pump, implantation, rat, iPRECIO, Physiological condition, SMP-200 pump

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Application Examples (AP) (page 16 eBook)
Author, doi/www			pg(s) number of eBook
Refillability of Pump		How pump programmed?
KVO/RCV	Vehicle and Drug(s)	Continuous	Intermittent or bolus	Circadian / Timed release
Adminstration Site		Duration
Key words
AP1 Tan et al. [doi:10.3389/fphar.2011.00044]			pg 16
3 days pump "OFF" (0.2ul/hour) , for control cardiovascular parameters	5-HT dose response with control period	No	Yes	Yes
SC		30 days
drug delivery, minipump, osmotic pumps, implantable pump, dose response, quantitative pharmacology, preclinical, telemetry, rat + SMP-200 pump
AP 2 Tan et al. [doi:10.3389/fphar.2011.00044]			pg 16
11 day recovery period	Saline, dobutamine and verapamil infusions	No	Yes	Yes
IV		30 days
drug delivery, minipump, osmotic pumps, implantable pump, dose response, quantitative pharmacology, preclinical, telemetry, rat + SMP-200 pump
AP 3 Zaretsky et al. < link >			pg 16
5 day recovery but no flow	BMI (0.1 mM) 100 nl injections	No	Yes	Yes
Intra-hypothalamic		several days
hypothalamas, cardiovasular, micro injections, rat + SMP-200 pump
AP 4 Kuroki et al. [doi:10.1152/ajpheart.00922.2013]			pg 16
7 to 10 days recovery then 4 days control period	5ul/hour continous infusion of Ang II. Comparison made with Alzet Pump and Havard Sringe pump	Yes	No	No
SC administration		2 weeks Ang II infusion
salt-sensitive hypertension; angiotensin II-salt hypertension; Alzet salt-sensitive hypertension; minipump; iPrecio pump; plasma angiotensin II
AP 5 Gey et al. [doi:10.1016/j.nbd.2016.03.012]			*Not in eBook
No RCV	0.2 ul/hr continuos infusion. Stability of vigabatrin was tested and confirmed for 5 weeks	Yes	No	No
Bilateral infusion into STN or anterior SNr		3 or 4 week
minipump; iPrecio pump; plasma angiotensin II, Rats, SMP-200

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Webinar (WE)
Author, www or doi			pg(s) number of eBook
Refillability of Pump		How pump programmed?
KVO/RCV	Vehicle and Drug(s)	Continuous	Intermittent or bolus	Circadian / Timed release
Adminstration Site		Duration
Key words
WE1 Schnell < link >			pgs 17-18
Saline infusion for tumor size to grow to a certain size (12th day)	On day 21 (tumor reached certain size), infusion of Compound A for 22 days. Behaviour and weight gain not impaired versus control without subcutaneous pump	Yes	No	No
Intra-cranial infusion		22 days
Cancer, orthotopic, glioblastoma, bioluminecscence, Nude rats, SMP-200
WE2 Doyle < link > (Henry et al. [doi:10.1210/en.2014-1825])			pgs 17-18
7 days recovery Saline, 5 days baseline Saline, 5 day TA or 10 day TA	Vitamin B12 Conjugation of Peptide-YY3–36 or Native Peptide-YY3–36 or saline 5 pulses per day; three 1 hour pulses of 10 nmol.kg-1.h-1 (20 μl.h-1) with three hours between pulses and two 1 hour pulses of 5 nmol.kg-1.h-1 (10 μl.h-1) with five hours between pulses	No	Yes	Yes
SC		5 or 10 days
endocrinology, vitamin B12, BBB, reduction of food intake, peptides, rats, SMP-200 pumps

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Recently in the news
Author, www or doi			pg(s) number of eBook
Refillability of Pump		How pump programmed?
KVO/RCV	Vehicle and Drug(s)	Continuous	Intermittent or bolus	Circadian / Timed release
Adminstration Site		Duration
Key words
Dey et al. [doi: 10.1161/CIRCRESAHA.118.312708]			pg 25
No	Daily bolus of Isoproterenol (ISO) was administered via implantation of a programmable iPRECIO® Pump in the peritoneal cavity. The iPRECIO pump enables reliable, timed delivery of pharmacological agents. The pump was programmed for 1 hour delivery of Isoproterenol at 30μl/hr, total dose of 2mg/kg/day, once a day at the same time (1 PM).	No	Yes	Yes
IP		3 to 5 weeks
ventricular fibrillation, phosphorylation, proteomics, heart failure, reactive oxygen species, mitochondria, 300g hartley guinea pig, SMP-200
Steplewski et al. [doi: 10.1002/jor.23369]			*New: Not in eBook.
No	The delivery of the ACA and P-ACA started immediately after surgery and continued for 8 weeks at 1ul/h.	Yes	No	No
Injured knee joint		8 weeks
joint contracture, posterior capsule collagen, collagen fibrils, arthrofibrosis, antibody, New Zealand White Rabbits, 8-12mths, SMP-200