Innovative drug infusion technology for laboratory animals.

Programmable      

Using the easy to use state of the art iPRECIO® software, header information along with infusion profile details are entered and ultimately downloaded to the pump's flash memory. Start Time, End Time, Flow-rate (0.0µl/hour to 10.0µl/hour), and infusion profiles maybe programmed. These profiles include sustained release, modified release, chrono release and pulsatile release. A total of 15 steps with repeat function allows both complex and simple infusion profiles to be programmed.
A recovery period may also be programmed using the Keep Vein Open Function (KVO) where saline is initially filled in the reservoir. A dead volume flushing function also ensures that the test article (TA) hits the animal at the programmed time point.

The programmable feature will make iPRECIO® pumps indispensable for applications where accurate flow infusion, recovery/washout periods, constant/variable dose or complex circadian infusion studies are necessary.

In-vivo (re)programming allows refinement and adjustments to be made after initial effects are measured/detected.

*subject to battery life

15 steps for flow rate or dose programming    Keep Vein Open (KVO) Function
Programming Workflow    Monitoring Function    Battery Life


15 steps for flow rate or dose programming : 0.0 - 10.0 ul/hr

infusion unit Each flow profile may contain up to 15 doses or flow rate steps. A single step would mean a fixed continuous dose or flow-rate for the study duration. (unless re-reprogrammed in-vivo) A more complex infusion profile will contain more than 1 step and may contain up to 15 steps.

group profile
In addition to the 15 steps, Repeat Mode may be used. Repeat Mode allows more complex infusions like circadian rhythm, modified release, chrono release and pulsative release to be programmed for daily/weekly/etc repeats.
group profile
circadian protocol



















Keep Vein Open (KVO) Function

A recovery period maybe programmed using the KVO function where saline or vehicle is infused to ensure patency of the catheter. During this time, the animal recovers from the implant surgery.

When using KVO mode, a function of the software allows to calculate the total dead volume of the catheter and pump to ensure that the test article (TA) or drug hits the animal at the programmed start time. Flushing of the dead volume maybe programmed by the user and the software automatically calculates when to exchange saline/vehicle to TA/drug.


Programming Workflow

Step1
Start of Study Design:
Study name, ID , user and date are input and saved.
Step2
Pumps and Animal Setting:
Here, total number of animals for study are entered and associated with an animal ID. Information including weight, sex, species, strain, administration site may be entered and saved.
Step3
Keep Vein Open (KVO) Setting
When requiring a recovery period following surgery, KVO setting maybe used to maintain catheter patency and also program a dead volume flush as a next step.
Step4
Infusion Protocol Setting
This is to program the TA or drug administration start time. It also includes the parameters for flushing the dead volume.

Communications Available (Comms Avail) is programmed in Group Prole/Infusion Protocol.


Monitoring Function

Monitor Function allows the user to follow the infusion profile in detail. Refill dates/exchange dates and alarms are also managed and displayed here.




Battery Life

The battery life is up to 52 days at a flow rate of 0.1μL/hr continuously. Battery life is calculated and estimated in iPRECIO® Software and this is dependent on pump switch on date, KVO duration, infusion profile and communication availability selected. These specications are subject to change for product improvements. Exact durations and calculations will be managed by the iPRECIO® Software. When used in preprogrammed (None/0 communication) mode battery life is maximized. When communications availability is set to 1 minute, maximum responsiveness is selected and this gives the lowest battery life.

    Communications availability does not mean that there will always be data or connection every minute.
    Actual data will be dependent on wireless environment and infusion protocol.

Communication
availability/
Logging interval
Per minute Every 2 hours Every 6 hours
Flow rate
(µL/hr)
Drive time(hours) Driving days(days) Drive time(hours) Driving days(days) Drive time(hours) Driving days(days)
0.1 403 16 907 37 1025 42
1.0 352 14 681 28 745 31
5.0 243 10 362 15 379 15
10.0 169 7 218 9
224 9
Communication
availability/
Logging interval
Every 24 hours∗ None ∗
Flow rate
(µL/hr)
Drive time(hours) Driving days(days) Drive time(hours) Driving days(days)
0.1 1104 45 1139 47
1.0 785 32 803
33
5.0 389 16 394 16
10.0 227 9 228 9

∗ Depending on wireless environment, infusion protocol programmed, communication availability/logging interval, pump logs maybe overwritten before being collected.
∗∗ Table above outlines the maximum battery life for the programmed protocol and pump switch on time. Exact battery life will be dependent on pump switch on time, programmed infusion protocol, and selected communication availability. iPRECIO Management software helps the user calculate battery life for selected programming.



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