Innovative drug infusion technology for laboratory animals.

Support Materials of iPRECIO®       

You can request for our support materials of your interest from our contact us page from this website.

Support Documents and Technical Notes   Bibliography   Free Full text articles in Pub Med Central


Support Documents and Technical Notes

Compatibility test <Compatible solvents/vehicles for iPRECIO>

You can request for our support materials of your interest from our contact us page from this website.

Frequently Asked Questions <FAQ>

This FAQ incorporates the most frequent question and answers for iPRECIO pumps.

Technical Note : Performance of the iPRECIO® Pumps.

Flow infusion accuracy of iPRECIO pumps (in-vitro testing). Contents of this technical note is included in the technology page. See Performance of iPRECIO pumps (in-vitro testing) page.

Technical Note : Recommendation for Intravenous Administration.

This technical note outlines best practice implantation for iPRECIO pumps for long term continuous administration.

*Includes recommendation of catheters and couplers.

Technical Note : Recommendations for Subcutaneous Administration.

This technical note defines best practice subcutaneous infusion administration site and iPRECIO pump placement and implantation.

Technical Note : Recommendations for Intraperitoneal Administration.

This technical note defines best practice intraperitoneal infusion administration site and iPRECIO pump placement and implantation.

Technical Note : Recommendations for Intracerebral Administration.

This technical note defines best practice intracerebral infusion administration site and iPRECIO pump placement and implantation. 322OP: Starter Kit Cranial Infusion Kit for iPRECIO® Pump and 322OP/Kit: Cranial Infusion Kit for iPRECIO® pump are supplied by Plastics One ® (www.plastics1.com).

Technical Note : Recommendations for Intrathecal Administration

This technical note defines the best practice intrathecal infusion administration using iPRECIO® pumps with customized intrathecal catheter part number 0220 from Recathco(www.recathco.com).

Technical Note : Materials Compatibility Kit for iPRECIO® Pump

This technical note defines the Standard Operating Procedure (SOP) for evaluating the compatibility of vehicle/solvents and agents to iPRECIO®.

Technical Note : SOPsfor fow validation of iPRECIO® pumps.

This technical note defines the Standard Operating Procedure (SOP) for flow accuracy validation based on residual/remaining solution in iPRECIO pumps.

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Bibliography

New publications

Dr. Femke Streijger, Miss Kitty So, Ms. Neda Manouchehri, Mr. Jae H.T. Lee, Dr. Elena B Okon, Ms. Katelyn Shortt, Ms. So-Eun Kim, Mr. Kurt Anthony McInnes, Dr. Peter Alec Cripton, and Dr. Brian K Kwon
Changes in Pressure, Hemodynamics and Metabolism Within the Spinal Cord During the First 7-days After Injury Using a Porcine Model
RJournal of Neurotrauma. August 2017
https://doi.org/10.1089/neu.2017.5034

Laure Penard, Karsten Skydsgaard, Christophe Bory, Edward Marsden
Challenges of intravenous infusion in the juvenile beagle dog
Reproductive Toxicology Volume 72, September 2017, Pages 46
http://www.sciencedirect.com/science/article/pii/S0890623817304689

C. Laloux, F. Gouel, C. Lachaud, K. Timmerman, B. Do Van, A. Jonneaux, M. Petrault, G. Garcon, N. Rouaix, C. Moreau, R. Bordet, J.A. Duce, J.C. Devedjian, D. Devos
Continuous cerebroventricular administration of dopamine: A new treatment for severe dyskinesia in Parkinson's disease?
Neurobiology of Disease http://dx.doi.org/10.1016/j.nbd.2017.03.013

Robert Andersson, Tobias Kroon, Joachim Almquist, Mats Jirstrand, Nicholas D. Oakes, Neil D. Evans, Michael J. Chappel, Johan Gabrielsson
Modeling of free fatty acid dynamics: insulin and nicotinic acid resistance under acute and chronic treatments
J Pharmacokinet Pharmacodyn | DOI 10.1007/s10928-017-9512-6 Accepted: 7 February 2017
https://link.springer.com/article/10.1007/s10928-017-9512-6

Masayuki Nakano, Yasuhisa Tamura, Masanori Yamatox, Satoshi Kume, Asami Eguchi, Kumi Takata, Yasuyoshi Watanabe & Yosky Kataoka
NG2 glial cells regulate neuroimmunological responses to maintain neuronal function and survival
Scientific Reports | 7:42041 | DOI: 10.1038/srep42041 Published: 14 February 2017
http://www.nature.com/articles/srep42041

Kroon T, Baccega T2, Olsén A, Gabrielsson J, Oakes ND
Nicotinic acid timed to feeding reverses tissue lipid accumulation and improves glucose control in obese Zucker rats[S].
J Lipid Res. 2017 Jan;58(1):31-41. doi: 10.1194/jlr.M068395. Epub 2016 Nov 15.
https://www.ncbi.nlm.nih.gov/pubmed/27875257

Hasan M. Zahid, MohammedZubaerul Ferdaus, HirokiOhara, Minoru Isomura & Toru Nabika
Effect of p22phox depletion on sympathetic regulation of blood pressure in SHRSP: evaluation in a new congenic strain
Scientific Reports | 6:36739 | DOI: 10.1038/srep36739 Published: 08 November 2016
http://www.nature.com/articles/srep36739

Rongwei Li, Kang Ma, Hengli Zhao, Zhou Feng, Yang Yang, Hongfei Ge, Xuan Zhang, Jun Tang, Yi Yin, Xin Liu, Liang Tan & Hua Feng
Cattle encephalon glycoside and ignotin reduced white matter injury and prevented post-hemorrhagic hydrocephalus in a rat model of intracerebral hemorrhage
Scientific Reports | 6:35923 | DOI: 10.1038/srep35923, 26 October 2016
http://www.nature.com/articles/srep35923

Helge Thisgaard, Bo Halle, Charlotte Aaberg-Jessen, Birgitte Brinkmann Olsen, Anne Sofie Nautrup Therkelsen, Johan Hygum Dam, Niels Langkjær, Sune Munthe, Kjell Någren, Poul Flemming Høilund-Carlsen, Bjarne Winther Kristensen
Highly Effective Auger-Electron Therapy in an Orthotopic Glioblastoma Xenograft Model using Convection-Enhanced Delivery
Theranostics 2016, Vol. 6, Issue 12 2016; 6(12): 2278-2291. doi: 10.7150/thno.15898
http://www.thno.org/v06p2278.pdf

Theodore A. Slotkin, Ashley Stadler, Samantha Skavicus, Jennifer Card, Jonathan Ruff, Edward D. Levin and Frederic J. Seidler
Is There a Critical Period for the Developmental Neurotoxicity of Low-Level Tobacco Smoke Exposure?
Toxicological Sciences 10.1093/toxsci/kfw180 Accepted September 6, 2016.
http://toxsci.oxfordjournals.org/content/early/2016/09/13/toxsci.kfw180.abstract

Tomonori Nakamura, Ikuhiro Okamoto, Kotaro Sasaki, Yukihiro Yabuta, Chizuru Iwatani, Hideaki Tsuchiya, Yasunari Seita, Shinichiro Nakamura,Takuya Yamamoto & Mitinori Saitou
A developmental coordinate of pluripotency among mice, monkeys and humans
Nature 537, 57–62 (01 September 2016) doi:10.1038/nature19096
Received 02 November 2015 Accepted 12 July 2016 Published online 24 August 2016
http://www.nature.com/nature/journal/v537/n7618/full/nature19096.html

A. Maleah Holland, Michael D. Roberts, Petey W. Mumford, Christopher Brooks Mobley, Wesley C. Kephart, Christine F. Conover, Luke A. Beggs, Alexander Balaez, Dana M. Otzel, Joshua F. Yarrow, Stephen E. Borst, Darren T. Beck
Testosterone inhibits expression of lipogenic genes in visceral fat by an estrogen-dependent mechanism
Journal of Applied Physiology Published 18 August 2016 Vol. no. , DOI: 10.1152/japplphysiol.00238.2016
http://jap.physiology.org/content/early/2016/08/16/japplphysiol.00238.2016.abstract

Vivi Flou Hjorth Jensen, Anne-Marie Mølck, Martin Mårtensson, Mette Aagaard Strid, Melissa Chapman, Jens Lykkesfeldt, Ingrid Brück Bøgh
Assessment of implantable infusion pumps for continuous infusion of human insulin in rats: potential for group housing
Lab Anim. 2016 Jul 27. pii: 0023677216660740. doi:10.1177/0023677216660740
http://lan.sagepub.com/content/early/2016/07/27/0023677216660740.abstract

Keisuke Shinohara, ToshimichiHata
Memory forgetting and NMDA receptor:Post-acquisition chronic microinfusionof NVP-AAM077 into dorsal hippocampus subsequently impairs the performance at reversal learning task in Morris water maze in rats
The 39thAnnual Meeting of the Japan Neuroscience Society, Oral Session Learning and Cognition: Hippocampus [O2-H-2-2] July 21, 2016
http://www.jnss.org/abstract/neuro2016/meeting_planner/sessiondetail.php?st_id=2016000289&u=1469585803&yz=0

Tobias Kroon
Optimizing Nicotinic Acid Delivery for Durable Antilipolysis and Improved Metabolic Control
Diss. (sammanfattning/summary) Uppsala : Sveriges lantbruksuniv., Acta Universitatis agriculturae Sueciae, 1652-6880 ; 2016:31 ISBN 978-91-576-8564-3 eISBN 978-91-576-8565-0
http://pub.epsilon.slu.se/13324/

R. Croft Thomas, Jr., Patrick M. Cowley, Abhishek Singh, Bat-Erdene Myagmar, Philip M. Swigart, Anthony J. Baker, Paul C. Simpson
The Alpha-1A Adrenergic Receptor in the Rabbit Heart
PLOS ONE | DOI:10.1371/journal.pone.0155238 June 3, 2016
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0155238

Toshiyuki Hamada, Kenneth Sutherland, Masayori Ishikawa, Naoki Miyamoto, Sato Honma, Hiroki Shirato & Ken-ichi Honma
In vivo imaging of clock gene expression in multiple tissues of freely moving mice
NATURE COMMUNICATIONS | 7:11705 | DOI: 10.1038/ncomms11705
http://www.nature.com/ncomms/2016/160610/ncomms11705/abs/ncomms11705.html

Joshua S. Speed & Kelly A. Hyndman
In vivo organ specific drug delivery with implantable peristaltic pumps
Scientific Reports 6, Article number: 26251 (2016) doi:10.1038/srep26251
http://www.nature.com/articles/srep26251

Yasunari Seita, Tomoyuki Tsukiyama, Chizuru Iwatani, Hideaki Tsuchiya, Jun Matsushita, Takuya Azami, Junko Okahara, Shinichiro Nakamura, Yoshitaka Hayashi, Seiji Hitoshi, Yasushi Itoh, Takeshi Imamura, Masaki Nishimura,Ikuo Tooyama, Hiroyuki Miyoshi, Mitinori Saitou, Kazumasa Ogasawara, Erika Sasaki & Masatsugu Ema
Generation of transgenic cynomolgus monkeys that express green fluorescent protein throughout the whole body
Scientific Reports | 6:24868 | DOI: 10.1038/srep24868
http://www.nature.com/articles/srep24868

Mitchell D., Read, K., Chapman M. and Patten
Intrathecal administration using the iPRECIO® implanted pump
Development in Life Sciences, Vol 14, No. 4
http://cdn2.hubspot.net/hubfs/212573/docs/Envigo/Envigo_Pharma_Dils_14.4.4.pdf?t=1460116975327

Laura Gey, Manuela Gernert, Wolfgang Löscher
Continuous bilateral infusion of vigabatrin into the subthalamic nucleus : Effects on seizure threshold and GABA metabolism in two rat models
Neurobiology of Disease Volume 91, July 2016, Pages 194–208 doi:10.1016/j.nbd.2016.03.012 http://www.sciencedirect.com/science/article/pii/S0969996116300560

C. Bory, P. Lege, E. Chalencon, J.-P. Briffaux, and S. Milano. WIL Research Europe, Lyon, France.
Pilot Study Investigating the Pressor Activity of Vasopressin Infused by the Subcutaneously Implanted SMP-200 Microinfusion Pump in the Telemetered Rat.
Poster P446, Society of Toxicology55th Annual Meeting, New Orleans, United States, March 13th to 17th 2016. http://www.criver.com/files/pdfs/nonsource/74198-wil-sot-2016-baudet-1-fin.aspx

E. Chalencon, C. Bory, J.-P. Briffaux, and S. Milano. WIL Research Europe, Lyon, France.
Hemodynamic Effects of Amlodipine Intravenously Infused for 6 Weeks by Implantable SMP-200 Microinfusion Pump in the Spontaneously Hypertensive (SH) Telemetered Rat.
Poster P448, Society of Toxicology 55th Annual Meeting, New Orleans, United States, March 13th to 17th 2016. http://www.criver.com/files/pdfs/nonsource/74256-wil-sot-2016-baudet-2-fin.aspx

Donna Tan, Ajai Vyas
Toxoplasma gondii infection and testosterone congruently increase tolerance of male rats for risk of reward forfeiture
Hormones and Behavior 79 (2016) 37–44
http://www.sciencedirect.com/science/article/pii/S0018506X16300204

Masaru Tsuboi,Yoshihide Ueda,Yasufumi Ota,Hiroshi Takehara,Takuya Aoshima,Fukutaro Mizuhashi
Physiological conditions in iPRECIO® -implanted rats
Fundamental Toxicological Sciences Vol.3 (2016) No.1 p.1-8
https://www.jstage.jst.go.jp/article/fts/3/1/3_1/_article

Bo Halle, Eric G. Marcusson, Charlotte Aaberg-Jessen, Stine S. Jensen, Morten Meyer, Mette K. Schulz, Claus Andersen, Bjarne W. Kristensen
Convection-enhanced delivery of an anti-miR is well-tolerated, preserves anti-miR stability and causes efficient target de-repression: a proof of concept.
Journal of Neuro-Oncology 2015 Oct 1.
http://link.springer.com/article/10.1007%2Fs11060-015-1947-2
http://www.ncbi.nlm.nih.gov/pubmed/26428358

T. Kroon, J. Gabrielsson, N.D. Oakes
The abruptness of terminating nicotinic acid delivery has a profound effect on free fatty acid and insulin rebound in rats
51st EASD Annual Meeting, Stockholm 2015
http://www.easdvirtualmeeting.org/resources/the-abruptness-of-terminating-nicotinic-acid-delivery-has-a-profound-effect-on-free-fatty-acid-and-insulin-rebound-in-rats--2

Christophe Bory, Philippe Legé, Estelle Chalencon, Stéphane Milano, WIL Research Europe Lyon, St Germain-Nuelles, France
Vasopressin pressor activity in telemetered rat infused with SMP 200 micro infusion pump. A pilot study
E-Posters: eP-54, 51st Congress of the European Societies of Toxicology, September 13th 2015
https://eurotox2015.abstract-management.de/program/index.php?conViewSession=5087&action=papers&showDay=

Estelle Chalencon, C. Bory and S. Milano
SMP-200 micro infusion pump: effect of 6-weeks intravenous treatment with Amlodipine in spontaneously hypertensive (SHR) telemetered rat
5th Infusion Technology Organization Meeting, September 7th-8th 2015, Cologne, Germany.
www.ito-org.eu

Laura Gey, W Löscher and M Gernert
Use of iPrecio implantable micro infusion pumps for targeted intracerebral drug delivery in a rat model of epilepsy
5th Infusion Technology Organization Meeting, September 7th-8th 2015, Cologne, Germany.
www.ito-org.eu

Christian Schnell
The harmony of gold standard physiological monitoring with novel infusion technology: Better quality of science in pre-clinical models ranging from mice to marmosets
5th Infusion Technology Organization Meeting, September 7th-8th 2015, Cologne, Germany.
www.ito-org.eu

K Drew, T Jinka, L Bogren, I Bailey, Z Carlson, J Olson
METHODS AND COMPOSITIONS FOR THE TREATMENT OF ISCHEMIC INJURY TO TISSUE USING THERAPEUTIC HYPOTHERMIA
US Patent 20,150,238,513, 2015
http://www.freepatentsonline.com/y2015/0238513.html

Andreas Lundt, Carola Wormuth, Magdalena Elisabeth Siwek, Ralf Müller, Dan Ehninger, Christina Henseler, Karl Broich, Anna Papazoglou, and Marco Weiergräber
EEG radiotelemetry in small laboratory rodents - a powerful state-of-the art approach in neuropsychiatric, neurodegenerative and epilepsy research -
Neural Plasticity
https://www.hindawi.com/journals/np/2016/8213878/

Leigh J. Williams, Stephanie K. Klein, Danielle Greenawalt, Dawn Trueman, Helen Musgrove, Helen Jones, Linette Ruston, and Barry R. Davies
Establishment of an orthotopic bladder cancer model to evaluate continuous intravesical delivery of small molecule inhibitors in the nude rat
AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA
http://cancerres.aacrjournals.org/content/75/15_Supplement/5146.short

Tobias Kroon, Ann Kjellstedt, Pia Thalén, Johan Gabrielsson, Nicholas D. Oakes
Dosing Profile Profoundly Influences Nicotinic Acid's Ability to Improve Metabolic Control in Rats
The Journal of Lipid Research, doi: 10.1194/jlr.M058149 , July 13, 2015
http://www.jlr.org/content/early/2015/07/13/jlr.M058149.abstract

Shanti Akers, Samuel GLickman, Serban A. Staicu, Deborah Haight, R. J. White
Increasing Dose Treprostinil and Tadalafil in Male Rats with Severe Pulmonary Hypertension
A52. PRECLINICAL TRIALS IN PULMONARY HYPERTENSION MODELS: NOVEL TARGETS AND DELIVERY.
May 1, 2015,A1954-A1954
http://www.atsjournals.org/doi/abs/10.1164/ajrccm-conference.2015.191.1_MeetingAbstracts.A1954

Tulasi Ram Jinka , Velva Combs , and Kelly L Drew
Translating drug-induced hibernation to therapeutic hypothermia
ACS Chem. Neurosci., March 26, 2015, DOI: 10.1021/acschemneuro.5b00056
http://pubs.acs.org/doi/abs/10.1021/acschemneuro.5b00056

Kohki Matsubara, Yoshihiro Matsushita, Kiyoshi Sakai, Fumiya Kano, Megumi Kondo, Mariko Noda, Noboru Hashimoto, Shiro Imagama, Naoki Ishiguro, Akio Suzumura, Minoru Ueda, Koichi Furukawa, and Akihito Yamamoto
Secreted Ectodomain of Sialic Acid-Binding Ig-Like Lectin-9 and Monocyte Chemoattractant Protein-1 Promote Recovery after Rat Spinal Cord Injury by Altering Macrophage Polarity
The Journal of Neuroscience, February 11, 2015 • 35(6):2452–2464
http://www.jneurosci.org/content/35/6/2452.short

Kelly E. Henry, Clinton T. Elfers, Rachael M. Burke, Oleg G. Chepurny,George G. Holz, James E. Blevins, Christian L. Roth, Robert P. Doyle
Vitamin B12 Conjugation of Peptide-YY3–36 Decreases Food Intake Compared to Native Peptide-YY3–36 Upon Subcutaneous Administration in Male Rats
Endocrinology February 6, 2015 doi: 10.1210/en.2014-1825
http://press.endocrine.org/doi/abs/10.1210/en.2014-1825

David C. Irwina, Jin Hyen Baekb,Kathryn Hassellc, Rachelle Nussc, Paul Eigenbergera, Christina Liska, Zoe Loomisc, Joanne Maltzahna, Kurt R Stenmarkd, Eva Nozik-Grayckd, Paul W. Buehlera
Hemoglobin induced lung vascular oxidation, inflammation, and remodeling contributes to the progression of hypoxic pulmonary hypertension and is attenuated in rats with repeat dose haptoglobin administration
Free Radical Biology and Medicine doi:10.1016/j.freeradbiomed.2015.01.012
http://www.sciencedirect.com/science/article/pii/S0891584915000192

Hiroshi Nakamoto, Kazuhiko Nakayama, Noriaki Emoto, and Fumihiko Kajiya
The Short-Term Effects of C-Peptide on the Early Diabetes-Related Ultrastructural Changes to the Podocyte Slit Diaphragm of Glomeruli in Rats
Microcirculation DOI: 10.1111/micc.12185
http://onlinelibrary.wiley.com/doi/10.1111/micc.12185/abstract

Shobha N. Bhattachar, David M. Bender, Stephanie A. Sweetana, James A. Wesley
Discovery Formulations: Approaches and Practices in Early Preclinical Development
Discovering and Developing Molecules with Optimal Drug-Like Properties
AAPS Advances in the Pharmaceutical Sciences Series Volume 15, 2015, pp 49-94 Chapter 2, 27 Sep 2014
http://link.springer.com/chapter/10.1007/978-1-4939-1399-2_2

Roy J. Haskell, Kimberly A. Foster, Ching Kim Tye, Michael Morgen
Enabling Discovery Through Leveraging and Miniaturizing Pharmaceutical Principles and Processes
Discovering and Developing Molecules with Optimal Drug-Like Properties
AAPS Advances in the Pharmaceutical Sciences Series Volume 15, 2015, pp 95-140 Chapter 3, 27 Sep 2014
http://link.springer.com/chapter/10.1007/978-1-4939-1399-2_3

Yamamoto A., Matsubara K., Kano F. and Sakai K.
Analysis of the Neuroregenerative Activities of Mesenchymal Stem Cells in Functional Recovery after Rat Spinal Cord Injury
Animal Models for Stem Cell Therapy
Methods in Molecular Biology Volume 1213, 2014, pp 321-328 Chapter 26 , 04 Aug 2014
http://link.springer.com/protocol/10.1007/978-1-4939-1453-1_26

Roth C.L, Clinton Elfers C., Henry K., Burke R. and Doyle R.P.
Testing the Vitamin B12 Dietary Pathway for Delivery of Peptide-YY
Endocrine Society's 96th Annual Meeting and Expo, June 21–24, 2014 – Chicago, United States.
http://press.endocrine.org/doi/abs/10.1210/endo-meetings.2014.OABA.5.SAT-0889

Kuroki M.T. . , Gregory D. Fink , John W. Osborn
Comparison of arterial pressure and plasma AngII responses to three methods of subcutaneous AngII administration
American Journal of Physiology - Heart and Circulatory PhysiologyJul 2014, DOI: 10.1152/ajpheart.00922.2013
http://ajpheart.physiology.org/content/early/2014/06/30/ajpheart.00922.2013

KROON T., THALÉN P., KJELLSTEDT A., GABRIELSSON J., OAKES N.D.,
Intermittent, but Not Continuous Nicotinic Acid (NiAc) Infusion Preserves Plasma Free Fatty Acid (FFA) Lowering and Ameliorates Insulin Resistance in Obese Zucker Rats
American Diabetes Association 74th Scientific Session, , San Francisco, CA, June 13-17th 2014
Poster #1823-P
http://ada.scientificposters.com/epsSearchADA.cfm

Naotaro Akiyama, MD, PhD; Tomomi Yamamoto-Fukuda, MD, PhD; Haruo Takahashi, MD, PhD
Influence of Continuous Negative Pressure in the Rat Middle Ear
The Laryngoscope , DOI: 10.1002/lary.24767
http://onlinelibrary.wiley.com/doi/10.1002/lary.24767/full

Kenji Suehiro, Yuka Nakamura, Shuai Xu, Youichi Uda, Takafumi Matsumura, Yoshiaki Yamaguchi, Hitoshi Okamura, Toshihide Yamashita & Yoshinori Takei
Ecto-domain phosphorylation promotes functional recovery from spinal cord injury
Scientific Reports 4,Article number:4972doi:10.1038/srep04972
http://www.nature.com/srep/2014/140515/srep04972/full/srep04972.html

Darren T. Beck Ph.D., Joshua F. Yarrow Ph.D., Luke A. Beggs M.S., Dana M. Otzel Ph.D., Fan Ye Ph.D., Christine F. Conover B.S., Julie R. Miller B.S., Alexander Balaez B.S., Sarah M. Combs B.S., Alicia M. Leeper B.S., Alyssa A. Williams B.S., Stephanie A. Lachacz B.S., Nigel Zheng Ph.D., Thomas J. Wronski Ph.D. and Stephen E. Borst Ph.D.
Influence of Aromatase Inhibition on the Bone Protective Effects of Testosterone
Journal of Bone and Mineral Research, 2014. DOI: 10.1002/jbmr.2265

Gey L, Gernert M, Löscher W
Chronic focal delivery of the antiepileptic drug vigabatrin into the subthalamic nucleus (STN) for epilepsy treatment
Deutsche Gesellschaft für Experimentelle und Klinische Pharmakologie und Toxikologie e.V. 80th Annual Meeting, April 1-3, Hannover, Germany.
Naunyn-Schmiedeberg's Arch Pharmacol (2014) 387 (Suppl1): S1-S113 (DOI 10.1007/s00210-014-0960-x)

Duncan Patten (Huntingdon Life Sciences, UK)
Use of iPRECIO implantable micro infusion pumps in rats
4th Infusion Technology Organization Meeting, May 8th-9th 2014, Harrogate, UK.

Christian R. Schnell (Oncology Research, Novartis, Switzerland)
Use of iPRECIO implantable micro infusion pumps in rats
4th Infusion Technology Organization Meeting, May 8th-9th 2014, Harrogate, UK.

Leigh Williams (Astrazeneca, UK)
Establishment of an orthotopic model of bladder cancer for evaluation of molecularly targeted agents; intravesical delivery.
4th Infusion Technology Organization Meeting, May 8th-9th 2014, Harrogate, UK.

Masanori Yamato, Yasuhisa Tamura, Asami Eguchi, Satoshi Kume, Yukiharu Miyashige, Masayuki Nakano, Yasuyoshi Watanabe, Yosky Kataoka
Brain Interleukin-1β and the Intrinsic Receptor Antagonist Control Peripheral Toll-Like Receptor 3-Mediated Suppression of Spontaneous Activity in Rats
Published: March 12, 2014 DOI: 10.1371/journal.pone.0090950 PLOS ONE Volume 9 Issue 3
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0090950

Noriko Arai-Nunota, Masahide Mizobuchi, Hiroaki Ogata, Ai Yamazaki-Nakazawa, Chiaki Kumata, Fumiko Kondo, Nozomu Hosaka, Fumihiko Koiwa, Eriko Kinugasa, Takanori Shibata, Tadao Akizawa
Intravenous Phosphate Loading Increases Fibroblast Growth Factor 23 in Uremic Rats
Published: March 13, 2014 DOI: 10.1371/journal.pone.0091096 PLOS ONE Volume 9 Issue 3
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0091096#pone-0091096-g004

Halle B., Marcusson E., Aaberg-Jessen C., Jensen S.S., Meyer M, Schulz M.K., Andersen C., Kristensen B.W.
Efficient microRNA inhibition in a highly invasive orthotopic glioblastoma model
4th Quadrennial Meeting of the World Federation of Neuro-Oncology
November 21-24, 2013, San Francisco, California

COTE M.P., HOULÉJ. D.
Chloride cotransporter KCC2 is essential to exercise-dependent recovery of spinal reflexes after SCI.
Neuroscience 2013, San Diego, USA. November 9th - 13th 2013
http://www.abstractsonline.com/Plan/ViewAbstract.aspx?sKey=7fc906d1-b705-4ea2-9148-1668c789f104&cKey=87ddc290-d4ac-4e6e-8bca-64232cf1e92c&mKey=%7b8D2A5BEC-4825-4CD6-9439-B42BB151D1CF%7d

OKON E. B., LEE J. H. T., STREIJGER F., MANOUCHEHRI N. , ANDERSON L. M., KWON B. K.
Intraparenchymal spinal cord microdialysis in unanaesthetized freely moving pigs following thoracic spinal cord injury
Neuroscience 2013, San Diego, USA. November 9th - 13th 2013
http://www.abstractsonline.com/Plan/ViewAbstract.aspx?sKey=26dc24fd-2afe-4922-aa98-271fb03f99fd&cKey=9bccf58f-6cc4-49d8-b1d8-25170efedd71&mKey=8d2a5bec-4825-4cd6-9439-b42bb151d1cf

Stanley W.C., Cox,J.W., Asemu G., O’Connell K.A., Dabkowski E.R., Xu W., Ribeiro R.F.Jr., Shekar K.C., Hoag S.W., Rastogi S., Sabbah H.N., Daneault C., Rosiers, C.
Evaluation of Docosahexaenoic Acid in a Dog Model of Hypertension Induced Left Ventricular Hypertrophy
Journal of Cardiovascular Translational Research, September 2013, DOI: 10.1007/s12265-013-9511-y
http://link.springer.com/article/10.1007/s12265-013-9511-y#

Beier H.
Pharmacokinetic application of the iPRECIO pump
DSI User Group Meeting, Berlin, Germany; March 21st & 22nd 2013

Imai T., Nakata E., Inoue K.
Inhibition of P2X4 receptor on spinal microglia attenuates mechanical allodynia in experimental autoimmune neuritis rats
Pain Research, Vol. 26 2011, O-59

Asemu G., O’Connell K.A., Cox J.W., Dabkowski E.R., Xu W., Ribeiro R.F. Jr., Shekar K.C., Hecker P.A. Rastogi S., Sabbah H.N., Hoppel C.L., and Stanley W.C.
Enhanced Resistance to Permeability Transition in Interfibrillar Cardiac Mitochondria in Dogs: Effects of Aging and Long Term Aldosterone Infusion
Am J Physiol Heart Circ Physiol ajpheart.00674.2012; published ahead of print December 15, 2012, doi:10.1152/ajpheart.00674.2012
http://ajpheart.physiology.org/content/early/2012/12/10/ajpheart.00674.2012.abstract?sid=1c8187a4-b1a5-41e2-9e88-20610af15128

Zaretsky D.V., Zaretskaia M.V., Durant P.J., Rusyniak D.E.
The use of microinfusion pump to perform intrahypothalamic injections in conscious rats.
Neuroscience 2012, New Orleans, USA., October 13th - 17 2012. http://www.abstractsonline.com/Plan/ViewAbstract.aspx?mID=2964&sKey=87d8b951-316f-466a-9eb7-4b154d0bbd2c&cKey=b4b8338f-9bd2-44e2-bcf4-6e05a36cbbcb&mKey=%7b70007181-01C9-4DE9-A0A2-EEBFA14CD9F1%7d

Patar, A., Jaafar, H., Jamalullail, S. M. S. S., & Abdullah, J. M.
The body wall crude extract of Stichopus variegatus promotes repair of acute contused spinal cord injury in rats by improving motor function and reduces intramedullary hemorrhage.
Biomed Res, 2012, 23(4), 483.22. http://biomedres.info/yahoo_site_admin/assets/docs/483-494-Jafri_Abdullahll-1.27425644.pdf

Sasaki N, Shinjo M, Hirakawa S, Nishinaka M, Tanaka Y, Mawatari K, Kitamori T, Sato K.
A palmtop-sized microfluidic cell culture system driven by a miniaturized infusion pump.
Electrophoresis. 2012 Jul;33(12):1729-35. doi: 10.1002/elps.201100691. http://www.ncbi.nlm.nih.gov/pubmed/22740461

Buehler PW, Baek JH, Lisk C, Connor I, Sullivan T, Kominsky D, Majka S, Stenmark KR, Nozik-Grayck E, Bonaventura J, Irwin DC.
Free hemoglobin induction of pulmonary vascular disease: evidence for an inflammatory mechanism.
Am J Physiol Lung Cell Mol Physiol. 2012 Aug;303(4):L312-26. Epub 2012 Jun 22. http://www.ncbi.nlm.nih.gov/pubmed/22728465

Yoshinori T., Kenji S., Kazuharu S., and Gozoh T.
Extracellular phosphorylation is a novel target for regenerative medicine against spinal cord injury. The FASEB Journal.
2012;26:921.4,
http://www.fasebj.org/cgi/content/meeting_abstract/26/1_MeetingAbstracts/921.4?sid=8d804f68-eb3f-4c2c-8b12-fa525cbbb359

Malicdan MC, Noguchi S, Tokutomi T, Goto Y, Nonaka I, Hayashi YK, and Nishino I.
Peracetylated N-acetylmannosamine, a synthetic sugar molecule, efficiently rescues muscle phenotype and biochemical defects in mouse model of sialic acid-deficient myopathy.
J Biol Chem. 2012 Jan 20; 287(4):2689-705. Epub 2011 Dec 8 http://www.ncbi.nlm.nih.gov/pubmed/22157763

Perron J., Frenette V., and Copeman C.
Validation and use of the iPRECIO® Micro Infusion Pump on GLP studies
Society of Toxicology Annual Meeting, San Francisco, United States, March 11th to 14th 2012.
http://www.criver.com/about-us/eureka/podcasts/july-2012/micro-infusion

Copeman C, Perron J., Trudel Y., Caron S., Emond F., Frenette, and Burr M.
Intraputamenal Infusion in the albino rat
Society of Toxicology Annual Meeting, San Francisco, United States, March 11th to 14th 2012.

Wood S.K., McFadden D.V., Grigoriadis D., Bhatnagar S. and Valentino R.J.
Depressive and cardiovascular disease co-morbidity in a rat model of social stress: a putative role for corticotropin-releasing factor
Psychopharmacology 2012 Feb 10. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/22322324

Imai T., Nakata E., Inoue K.
Inhibition of P2X4 receptor on spinal microglia attenuates mechanical allodynia in experimental autoimmune neuritis rats
Pain Research, Vol. 26 2011, O-59 Accepted: 7 February 2012
https://www.jstage.jst.go.jp/article/pain/27/1/27_4/_pdf

Clarke I.J., Smith J.T., Henry B.A., Oldfield B.J., Stefanidis A., Millar R.P., Sari I.P., Chng K., Fabre-Nys C., Caraty A., Ang B.T., Chan L., and Fraley G.S.
Gonadotropin-Inhibitory Hormone Is a Hypothalamic Peptide That Provides a Molecular Switch between Reproduction and Feeding.
Neuroendocrinology (DOI: 10.1159/000332822) First published online January 25, 2012.
http://www.ncbi.nlm.nih.gov/pubmed/22286004

Kusanagi A., Yamasaki J., Iwatani C., Tsuchiya H. and Torii R.
220 NONHUMAN PRIMATE EMBRYONIC STEM CELLS SIMILAR TO THE BIOLOGICAL PROPERTIES OF MOUSE EMBRYONIC STEM CELLS
Reproduction, Fertility and Development 24(1) 222-222 http://dx.doi.org/10.1071/RDv24n1Ab220

Iwatani C., Yamasaki J., Kusanagi A., Tsuchiya H. and Torii R.
127 Ovarian stimulation in cynomolgus monkeys by a controlled release of follicular-stimulating hormone utilizing a micro infusion pump.
Reproduction, Fertility and Development 24 (1) 176-176 http://dx.doi.org/10.1071/RDv24n1Ab127

Tan T., Watts S. W. and Davis R. P.
Drug delivery: enabling technology for drug discovery and development. iPRECIO Micro Infusion Pump: programmable, refillable, and implantable.
Front. Pharmacol. 2:44. doi: 10.3389/fphar.2011.00044 [click here] to access full article on www.frontiersin.org

Osborn J., presenter; Fink G., discussant
Implantable infusion pumps for chronic rodent studies.
Workshop: Rodent Instrumentation Workshop M. Knuepfer, Experimental Biology, Washington DC.; April 9th to 13th 2011
http://medschool.slu.edu/pharmphys/uploads/John_Osborn_Implantable_Infusion_Pumps.pdf

Yoshinori T.,
Extracellular protein phosphorylation promotes functional recovery from experimental spinal cord injury.
The 6th International Symposium on Receptor Mechanisms, Signal Transduction and Drug Effects
- Development of Novel Therapy to Specific Disease in organ -, Kyoto, Japan; April 1st and 2nd 2011

Schnell C. and Ferrat T.,
Use of novel programmable pump for intracranial administration in an orthotopic glioblastoma tumor model in rats.
DSI User Group Meeting, Paris, France; March 17th 18th 2011

Martel E.
Refined rat pharmacology studies with infusion using implantable pumps.
DSI User Group Meeting, Paris, France; March 17th 18th 2011

Douglas G., Jones H., Edgington A., Saunders K., Neil Morgan S, Pullen N and Parenty G.
GPR54 agonists a way forward for downregulation of the GnRH pathway?
10th International Symposium on GnRH, Salzburg, Austria, Feb 6th -8th 2011

Shobo M., Yamada H., Koakutsu A., Hamada N., Fujii M, Harada K., Ni K., and Matsuoka N.,
Chronic treatment with olanzapine via a novel infusion pump induces adiposity in male rats.
Life Sciences, Volume 88, Issues 17–18, 25 April 2011, Pages 761-765 [ http://www.ncbi.nlm.nih.gov/pubmed/21356217]

Chikara Abe, Kunihiko Tanaka, Chihiro Iwata, and Hironobu Morita
Vestibular-mediated increase in central serotonin plays an important role in hypergravity-induced hypophagia in rats
J Appl Physiol, 2010 Sep 16 [Epub ahead of print]; [PubMed Link]

Yamato M., Okuyama K., Jin GH., Eguchi A., Watanabe Y., Kataoka Y.
Endogenous IL-1β and IL-1 receptor antagonist in the brain are involved in poly I:C-induced immunological fatigue
The 33rd Annual Meeting of the Japan Neuroscience Society, Kobe, Japan., September 2nd – 4th 2010.

Stephanie W. Watts
The Evolving Story of 5-HT and Blood Pressure Mechanisms in a Muddle
Serotonin Club 2010, Montreal, Canada, July 9-11 2010

Susan K. Wood
Insights into pharmacotherapy for co-morbid depression and cardiovascular disease using a rodent model of social stress
iPRECIO® Luncheon Seminar, EB2010, Anaheim, United States, April 20-24 2010

Patrick Davis, Gregory D Fink, Bridget Seitz, and Stephanie W Watts
Serotonin infusion via the iPrecio® micro infusion pump results in repeated reductions in blood pressure in the normotensive Sprague Dawley rat.
FASEB J. 2010 24:lb551 [Abstract in the FASEB Journal]

Jay Gizzi, Theodore Baird, Kyle O'Donohue, Josh Yoder, Jessica Grenwis, and Heather Bogie
Optimization of a fully implantable small animal infusion model involving multi-pressure data collection.
FASEB J. 2010 24:lb571 [Abstract in the FASEB Journal]

Shobo M., Yamada H., Koakutsu A., Harada K., Ni K., and Matsuoka N.
Effect of long-term electrical infusion of olanzapine on fat weight in rats: a novel method for administration of biologically and/or chemically fragile compounds.
The 83rd Annual Meeting of the Japanese Pharmacological Society, Osaka, Japan, March 16th -18th 2010

Abe C., Tanaka K., Awazu H., Morita H.
The role of the vestibular system on the metabolism under hypergravity environment in rats: Implication for motion sickness.
Neuroscience 2009, Chicago, USA., October 17th - 21st 2009.

Yamato M., Okuyama K., Jin GH., Eguchi A., Watanabe Y., Kataoka Y.
Interleukin-1 β expression in the brain is involved in poly I:C-induced immunological fatigue-like behavior in rats
The 32nd Annual Meeting of the Japan Neuroscience Society, Nagoya, Japan., September 16th - 18th 2009.

Coles D.I., Warr A., Mead A.
Characterization of Pentobarbital Physical Dependance and Withdrawal in Rats
9th. Safety Pharmacology Society Annual Meeting, Strasbourg, France., September 15th - 18th 2009. http://www.sciencedirect.com/science/article/pii/S1056871910001905

Infusion Pumps for Small Laboratory Animals
ALN Magazine May/June 2009
http://www.alnmag.com/article/infusion-pumps-small-laboratory-animals

Iwatani C., Yamasaki J., Okahara-Narita J.,Tsuchiya H., Torii R.
Research Center for Animal Life Science Shiga University of Medical Science
Follicular stimulation with micro infusion pump in cynomolgus monkeys (Macaca fascicularis)
The 56th Annual Meeting of the Japanese Association for Laboratory Animal Science 2009, Omiya Sonic City, Japan., May13th - 16th 2009.

Abe C, Tashiro T, Tanaka K, Ogihara R, Morita H.
A novel type of implantable and programmable infusion pump for small laboratory animals.
J Pharmacol Toxicol Methods. 2008 Sep 22. [PubMed Link]

Emiko Matsuoka, Makoto Miyazaki, Kazunori Iwanaga, and Masao Kakemi.
Assessment of Pharmacokinetic-Pharmacodynamic Relationship of Vitamin B12 in the Treatment of Somnipathy in Rats
14th Annual Meeting of Japanese Society for Chronobiology, Tokyo, Japan, November 7-9 2007

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Free Full text articles in Pub Med Central

Administration of Substances to Laboratory Animals
All published 2011.

Administration of Substances to Laboratory Animals: Equipment Considerations, Vehicle Selection, and Solute Preparation
Patricia V Turner, Cynthia Pekow, Mary Ann Vasbinder, and Thea Brabb
J Am Assoc Lab Anim Sci. 2011 September; 50(5): 614–627. Published online 2011 September. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189663/?tool=pmcentrez

Administration of Substances to Laboratory Animals: Routes of Administration and Factors to Consider
Patricia V Turner, Thea Brabb, Cynthia Pekow, and Mary Ann Vasbinder
J Am Assoc Lab Anim Sci. 2011 September; 50(5): 600–613. Published online 2011 September. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189662/?tool=pmcentrez

Drug Delivery: Enabling Technology for Drug Discovery and Development. iPRECIO® Micro Infusion Pump: Programmable, Refillable, and Implantable
Tsung Tan, Stephanie W. Watts, and Robert Patrick Davis
Front Pharmacol. 2011; 2: 44. Published online 2011 July 29. doi: 10.3389/fphar.2011.00044 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149148/?tool=pmcentrez

 

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