Innovative drug infusion technology for laboratory animals.

iPRECIO®      

The table below summarizes selected example use of iPRECIO® in Japan. These pumps have mainly been used in rats but have also been used in goat, non human primates, rabbits and guinea pigs. Due to iPRECIO® pumps small size, good accuracy and functionality, they have also been used with mice with a tether system where they replaced the syringe pump. With such a compact system; animal, cage and pump may be isolated very easily, for example isolated and metabolic cages.

The technology report summarizes additional application details from various publications and includes 5 examples from United States and Europe:-
  1. Dependence and withdrawal in the same cohort
  2. Rapid and long term delivery of drug with radiotelemetry (blood pressure endpoint)
  3. Dose response curve within an individual animal with radiotelemetry (blood pressure endpoint)
  4. Dose response of multiple drugs, within a single animal with radiotelemetry (systemic and ventricular pressure endpoints)
  5. Drug exposure levels in blood for 3 dose profiles (PK)
Customer Animal Drug Administration Route Mode Flow-rate
Pharmaceutical Company Rat The toxicity test of a circulation related medicine External jugular vein Confidential Confidential
Pharmaceutical Company Rat Reproductive hormone External jugular vein RCV/Constant 5-10
Pharmaceutical Company Rat Diabetes related medicine External jugular vein RCV/Variable 3-15
Pharmaceutical Company Rat Epilepsy related medicine Injection in the skull RCV/Constant 1-10
Pharmaceutical Company Rat Antiphlogistic-sedative-drug relation Subcutaneous RCV/Constant 1-20
Pharmaceutical Company Rat Ophthalmology region medicine Fundus oculi RCV/Constant 3-15
Pharmaceutical Company Rat Metabolism related External jugular vein RCV/Constant 5-10
Pharmaceutical Company Rat pH5 strong acidity solution Subcutaneous Confidential Confidential
Fukuyama University Rat Pain Subcutaneous Confidential Confidential
Gifu university Rat Angiotensin 2 External jugular vein Instant/Variable 3-30
Losartan
Hoshi University Hamster Confidential External jugular vein and Subcutaneous RCV/Constant 1-15
Hoshi University Rat Confidential External jugular vein RCV/Constant 5-30
Hoshi University Rat pain clinic related Hypodermoclysis RCV/Constant 1-30
Jichi Medical University Mouse Confidential Subcutaneous Confidential Confidential
Nagoya City University Rat Angiotensin 2 External jugular vein Confidential Confidential
National Institute of Agrobiological Sciences Goat Confidential Vein RCV/Constant 5-30
National Center of Neurology and Psychiatry (NCNP) Mouse Confidential Subcutaneous RCV/Constant 1-15
Nihon University Rat Confidential External jugular vein RCV/Constant 3-10
Osaka City University Rat Neurotransmitter Injection in the skull RCV/Constant 1-15
Osaka University of Pharmaceutical Sciences Rat VitamineB12 External jugular vein Confidential Confidential
Shiga University of Medical Science Confidential Reproduction related Subcutaneous Instant/Variable 1-7
Shiga University of Medical Science Rat Reproductive hormone External jugular vein RCV/Constant 5-10
Tokyo Women's Medical University (TWMU) Hamster Confidential External jugular vein and Subcutaneous RCV/Constant 1-15
The University of Tokyo Rat Nicotine External jugular vein Confidential Confidential
The University of Tokyo Rat Confidential External jugular vein RCV/Constant 5-15

 

For more details on applications, see bibliography section (here) and iPRECIO® Application and Technology Report (here)

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