Congratulations Arialys Therapeutics on your new peer-reviewed data published in Nature Communications demonstrating the potential of your lead candidate, ART5803, to address anti-NMDA receptor encephalitis and related autoimmune neuropsychiatric diseases. First time for us to see our SMP-200 pumps used for disease induction and disease treatment in a peer reviewed publication.

Kanno, A., Kito, T., Maeda, M. et al. Monoclonal humanized monovalent antibody blocking therapy for anti-NMDA receptor encephalitis. Nat Commun 16, 5292 (2025). https://doi.org/10.1038/s41467-025-60628-1

Latest references updated. For our latest iPRECIO Applications Examples and Tabular highlights, contact us by e-mail to iprecio@primetech.co.jp or through our contact form. https://www.iprecio.com/contact/form/tabid/231/Default.aspx

Important News – Incompatible Analgesic containing MCT Oil

We have found that Ethiqa XR long acting analgesia which contains MCT oil is not compatible with iPRECIO pumps. The use of Ethiqa XR as analgesic has been found to weaken iPRECIO pump reservoir and cause leaks. More significant damage has also occurred. We recommend not to use Ethiqa XR or any analgesic formulations containing oils. If the use of Ethiqa XR is important, please contact Primetech Corporation for further information.

Finally, as a reminder, iPRECIO Pumps are not compatible with oils as vehicle and oils will weaken and will destroy the reservoir and catheter.

Christian Schnell's (Novartis Oncology) talk on "Challenges in enabling translation of tumor models in cancer therapy: Exploiting secreted luciferases to monitor tumor metastasis as a promising approach" at the Swiss 3Rs Day 2024 in the AGORA Cancer Research Centre in Lausanne. Recording sponsored by Primetech Corporation – makers of iPRECIO^® Programmable Pumps.

https://www.youtube.com/watch?v=7Tcdb4L3gCY

Sponsored 2024 3Rs Sharing Conference April 17, 2024
Genentech Campus, San Francisco, California
An in-person discussion-focused 3Rs conference hosted by the 3Rs Collaborative and the New Jersey Association for Biomedical Research.

Check out agenda https://3rc.org/3rs-sharing-conference/

Published: 30 January 2024 from Genentech, 1 DNA Way, South San Francisco,
An, Le, Tom De Bruyn, Jodie Pang, Savita Ubhayakar, Laurent Salphati, Xing Zhang, Liling Liu et al. "Early Stage Preclinical Formulation Strategies to Alter the Pharmacokinetic Profile of Two Small Molecule Therapeutics." Pharmaceuticals 17, no. 2 (2024): 179.
https://www.mdpi.com/1424-8247/17/2/179

Keywords: drug delivery; PO; IV infusion; IP; SC; small molecule; PK profile; exposure